{"id":"W4200100973","doi":"10.1182/blood-2021-148009","title":"Primary Analysis of ZUMA-12: A Phase 2 Study of Axicabtagene Ciloleucel (Axi-Cel) As First-Line Therapy in Patients with High-Risk Large B-Cell Lymphoma (LBCL)","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Medicine; Internal medicine; B-cell lymphoma; Oncology; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00372089,0.001953824,0.002290236,0.0005070741,0.0005144128,0.001320686,0.0009534699,0.001324995,0.006066417],"category_scores_gemma":[0.001234485,0.0008160213,0.001790597,0.0004170382,0.0007787221,0.0007263792,0.0005173464,0.00263951,0.001471612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009793843,"about_ca_system_score_gemma":0.0020753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005835854,"about_ca_topic_score_gemma":0.001951963,"domain_scores_codex":[0.999122,0.0004723527,0.00003298275,0.0001693664,0.00006743024,0.000135915],"domain_scores_gemma":[0.9990159,0.0001503532,0.0001793021,0.0001118251,0.0001037638,0.0004387502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7982421,0.05537308,0.01271811,0.001694684,0.003787706,0.0003220101,0.0002872864,0.003077261,0.05344718,0.0003504736,0.007726452,0.06297371],"study_design_scores_gemma":[0.5703482,0.3867637,0.02360927,0.00007263374,0.002302784,0.0004481897,0.00008003264,0.001714982,0.00737641,0.0003447082,0.006896462,0.00004262456],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747517,0.003693436,0.001784687,0.0006083938,0.0001716387,0.01035354,0.005237565,0.0003453195,0.003053665],"genre_scores_gemma":[0.9723338,0.001539497,0.003368495,0.001120818,0.00022825,0.01002139,0.006558069,0.0001121964,0.004717498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006066417,"threshold_uncertainty_score":0.02029419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01367928703810863,"score_gpt":0.2767884265289065,"score_spread":0.2631091394907978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}