{"id":"W4200101053","doi":"10.1161/circulationaha.121.055459","title":"Effect of the Glucagon-Like Peptide-1 Receptor Agonists Semaglutide and Liraglutide on Kidney Outcomes in Patients With Type 2 Diabetes: Pooled Analysis of SUSTAIN 6 and LEADER","year":2021,"lang":"en","type":"article","venue":"Circulation","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":238,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Novo Nordisk; Steno Diabetes Center Copenhagen","keywords":"Semaglutide; Liraglutide; Medicine; Glucagon-like peptide 1 receptor; Glucagon-like peptide-1; Type 2 diabetes; Internal medicine; Exenatide; Dulaglutide; Diabetes mellitus; Endocrinology; Lixisenatide; Receptor; Agonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000165296,0.0001204806,0.0004063269,0.0001870804,0.00002632588,0.000008987655,0.0000262573,0.00004121161,0.00001691905],"category_scores_gemma":[0.0002086892,0.00007601113,0.00006630105,0.0006044285,0.00005717771,0.00003927617,0.00003226502,0.00005068308,7.727216e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006302384,"about_ca_system_score_gemma":0.00003194743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001712758,"about_ca_topic_score_gemma":0.00001678687,"domain_scores_codex":[0.9991643,0.0001024073,0.0001976054,0.0002005254,0.0002082388,0.000126875],"domain_scores_gemma":[0.999382,0.0001132115,0.0001160898,0.0002392593,0.00009809102,0.00005137629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001129198,0.000156958,0.9942791,0.0002483807,0.001214537,0.000001009943,0.0001726266,0.0001501822,0.0007155537,0.0000319367,0.00004773054,0.002869018],"study_design_scores_gemma":[0.002408108,0.0003490339,0.9912474,0.0001782736,0.002420497,3.953996e-8,0.00004716502,0.0004443212,0.002776814,0.000007386036,0.00005364776,0.00006729895],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989538,0.0001103175,0.000003082987,0.0002402842,0.00004833416,0.0004720356,0.000008332733,0.000007872284,0.0001559781],"genre_scores_gemma":[0.9994009,0.000007495226,0.00003543165,0.0002023977,0.000004762648,0.000009220662,0.0001421643,0.00001044578,0.0001871888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003031731,"threshold_uncertainty_score":0.3099644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005272779020068145,"score_gpt":0.2297532873355616,"score_spread":0.2244805083154934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}