{"id":"W4200108738","doi":"10.1182/blood-2021-147983","title":"Cevostamab Monotherapy Continues to Show Clinically Meaningful Activity and Manageable Safety in Patients with Heavily Pre-Treated Relapsed/Refractory Multiple Myeloma (RRMM): Updated Results from an Ongoing Phase I Study","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Multiple myeloma; Cytokine release syndrome; Internal medicine; Lenalidomide; Adverse effect; Refractory (planetary science); Cohort; Oncology; Cancer; Immunotherapy; Chimeric antigen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002335824,0.0004655459,0.001631439,0.0002859039,0.000208545,0.001155425,0.0004844031,0.0004494232,0.001761447],"category_scores_gemma":[0.002339439,0.0001661534,0.001260793,0.0005608783,0.000265773,0.0007484922,0.0002260232,0.001255634,0.0003664152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007105854,"about_ca_system_score_gemma":0.0007160491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007197377,"about_ca_topic_score_gemma":0.002265726,"domain_scores_codex":[0.9992841,0.0002777753,0.00007796263,0.00009504447,0.0001732863,0.00009185138],"domain_scores_gemma":[0.99795,0.0006275318,0.000672179,0.0001639702,0.0003186865,0.0002676805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.0931331,0.003315206,0.04858313,0.002805066,0.005415811,0.0002069995,0.0002660417,0.002209573,0.05788103,0.0003082355,0.01219781,0.7736779],"study_design_scores_gemma":[0.07116066,0.319701,0.4437523,0.001397125,0.01652092,0.002950037,0.0003628536,0.004373365,0.04206523,0.001247747,0.09628948,0.0001792477],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.921972,0.06273379,0.001748397,0.001579506,0.0001872473,0.0006494659,0.003806541,0.0002197835,0.007103248],"genre_scores_gemma":[0.9729505,0.01557742,0.001833901,0.00197894,0.0002112182,0.0003953684,0.005836233,0.00005911888,0.001157244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002335824,"threshold_uncertainty_score":0.01235312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01796555363184307,"score_gpt":0.3122577428817261,"score_spread":0.294292189249883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}