{"id":"W4200108738","doi":"10.1182/blood-2021-147983","title":"Cevostamab Monotherapy Continues to Show Clinically Meaningful Activity and Manageable Safety in Patients with Heavily Pre-Treated Relapsed/Refractory Multiple Myeloma (RRMM): Updated Results from an Ongoing Phase I Study","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Multiple myeloma; Cytokine release syndrome; Internal medicine; Lenalidomide; Adverse effect; Refractory (planetary science); Cohort; Oncology; Cancer; Immunotherapy; Chimeric antigen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004359098,0.0003932346,0.0007857021,0.0001993812,0.0001629557,0.0001001355,0.0001462918,0.0001546076,0.00005760715],"category_scores_gemma":[0.000649726,0.0003222652,0.00006320516,0.0004797642,0.00006117364,0.0003499662,0.0001284188,0.0004246941,0.00001160026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001217693,"about_ca_system_score_gemma":0.0001784666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002582512,"about_ca_topic_score_gemma":0.00451713,"domain_scores_codex":[0.99654,0.0004198769,0.0006638351,0.001148455,0.0006407333,0.0005871475],"domain_scores_gemma":[0.9975415,0.0004525488,0.0001926317,0.0009087772,0.0003229264,0.0005816542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.06370541,0.03008841,0.8654118,0.0000167623,0.0008368787,0.001235566,0.001788019,0.00000507545,0.004386008,3.099906e-7,0.00003639247,0.03248938],"study_design_scores_gemma":[0.1590568,0.008520484,0.8252444,0.000204257,0.0001921621,0.000003074061,0.0003982301,0.0002018441,0.005730233,0.000002419813,0.0001830119,0.0002630683],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962528,0.00007216958,0.00002169809,0.0001696907,0.00003611124,0.002470888,0.0005772583,0.0001284033,0.0002710314],"genre_scores_gemma":[0.9962721,0.00004433373,0.001749263,0.0001333658,0.00005441309,0.00007359966,0.001259504,0.00007221553,0.0003411456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09535142,"threshold_uncertainty_score":0.9999229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01796555363184307,"score_gpt":0.3122577428817261,"score_spread":0.294292189249883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}