{"id":"W4200113611","doi":"10.1101/2021.12.26.474206","title":"PITA, a pre-bilaterian p75NTR, is the evolutionary ancestor of TNF receptors","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Okanagan University College; McGill University; University of British Columbia, Okanagan Campus; University of British Columbia; Montreal Neurological Institute and Hospital","funders":"","keywords":"Biology; Phylum; Ancestor; Evolutionary biology; Tumor necrosis factor receptor; Genetics; Gene; Receptor; History","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001526952,0.0002357307,0.0002163387,0.0003853031,0.0006551526,0.0004929394,0.0002682341,0.0003016318,0.001759346],"category_scores_gemma":[0.0002105343,0.0001727559,0.0003736713,0.0003906992,0.0004314565,0.0004675357,0.0006438197,0.0006247656,0.0007657004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003843056,"about_ca_system_score_gemma":0.0003691421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009403801,"about_ca_topic_score_gemma":0.001376709,"domain_scores_codex":[0.9998604,0.000009975605,0.000008757886,0.0000519587,0.00004414319,0.00002479401],"domain_scores_gemma":[0.9998387,0.00001338913,0.00007579794,0.00001744046,0.00002222392,0.00003245567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004606177,0.00002453339,0.01999386,0.0001731598,0.00003899432,0.0009846537,0.0001568258,0.0003751798,0.9498498,0.00283097,0.0005035627,0.0246079],"study_design_scores_gemma":[0.0001291505,0.001258607,0.3018911,0.0001203611,0.0002466026,0.01314287,0.0008015371,0.007631788,0.5545823,0.00321735,0.1168918,0.00008643805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729478,0.002487362,0.01617925,0.0002192885,0.00006667542,0.0000705479,0.00143289,0.0003357407,0.006260486],"genre_scores_gemma":[0.98132,0.0008149347,0.01263717,0.0001148069,0.00002015681,0.0000286685,0.001625807,0.00003482007,0.003403774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001759346,"threshold_uncertainty_score":0.005885601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007802516789801051,"score_gpt":0.2039600375622774,"score_spread":0.1961575207724764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}