{"id":"W4200113851","doi":"10.1158/1535-7163.targ-21-p136","title":"Abstract P136: Response to alpelisib in an adolescent with <i>PIK3CA</i>-mutated metastatic gastrointestinal stromal tumour","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Gastrointestinal Tumor Research and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"PDGFRA; SDHB; Stromal tumor; Sunitinib; GiST; Cancer; CD117; Germline; Cancer research; Germline mutation; Pathology; Imatinib; Internal medicine; Biology; Medicine; Oncology; Stromal cell; Mutation; CD34; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001597857,0.0004493653,0.0005630828,0.0006052257,0.0008658659,0.000423178,0.0004591932,0.001759137,0.001787902],"category_scores_gemma":[0.0008572727,0.0001871541,0.0005496597,0.0003722809,0.0004444312,0.0005817145,0.0003471025,0.002142085,0.0004935591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001036443,"about_ca_system_score_gemma":0.0005215771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002442831,"about_ca_topic_score_gemma":0.003682337,"domain_scores_codex":[0.9998282,0.00001854346,0.0000195104,0.00004832732,0.00003027559,0.00005501402],"domain_scores_gemma":[0.9995657,0.00008251533,0.00005105349,0.00001220111,0.00004057069,0.0002481373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0001598377,0.0001171959,0.02905701,0.00004599701,0.00001861644,0.9621812,0.0001620206,0.0002753554,0.001858946,0.0002011629,0.001423235,0.004499408],"study_design_scores_gemma":[0.0000689208,0.0009085941,0.06355542,0.0001247689,0.00004600179,0.9280149,0.0003820164,0.001971638,0.001005144,0.0005780599,0.003315892,0.00002864377],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9677274,0.003259155,0.001344808,0.01469172,0.0005461308,0.0001697867,0.0005995077,0.0001449548,0.01151657],"genre_scores_gemma":[0.996566,0.0005120665,0.0003330311,0.001405483,0.0001780322,0.00001340377,0.0001502817,0.00001266736,0.0008290843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002442831,"threshold_uncertainty_score":0.007519901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0441469780952872,"score_gpt":0.3455051166161648,"score_spread":0.3013581385208776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}