{"id":"W4200116858","doi":"10.1182/blood-2021-147618","title":"Spleen and Symptom Responses with Fedratinib (FEDR) in Patients with Myelofibrosis (MF) and Substantial Splenomegaly","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Myelofibrosis; Ruxolitinib; Internal medicine; Gastroenterology; Placebo; Clinical trial; Spleen; Phases of clinical research; Surgery; Bone marrow; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007843935,0.0002171805,0.0005992119,0.0002125563,0.0002021606,0.0003260256,0.0001692603,0.0002458948,0.001274455],"category_scores_gemma":[0.001125834,0.0001240372,0.0004767333,0.0002146819,0.0001758886,0.0003257465,0.0002108654,0.0006492968,0.0001679745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003801475,"about_ca_system_score_gemma":0.0002875863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004942067,"about_ca_topic_score_gemma":0.001115754,"domain_scores_codex":[0.9998179,0.00007119751,0.00002199364,0.00003449196,0.0000304926,0.00002385366],"domain_scores_gemma":[0.9993297,0.000173164,0.000237151,0.00002339155,0.0000502138,0.0001863087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1139924,0.003751598,0.693547,0.0008178696,0.001221939,0.001616999,0.0004106829,0.001886036,0.02054287,0.0001680296,0.003180367,0.1588643],"study_design_scores_gemma":[0.005928097,0.05692491,0.9233707,0.0001230568,0.0007655664,0.004378827,0.0002506365,0.00180151,0.003220402,0.0001718055,0.003029598,0.0000349659],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976241,0.00139737,0.00005535319,0.0001121678,0.000009933541,0.00003235424,0.0002083928,0.000007480866,0.00055281],"genre_scores_gemma":[0.9992077,0.0002011953,0.0001003678,0.00007847882,0.00001762311,0.00001707982,0.0002504057,6.977335e-7,0.0001264594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001274455,"threshold_uncertainty_score":0.00426352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006340998219413477,"score_gpt":0.2123489159111804,"score_spread":0.2060079176917669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}