{"id":"W4200119638","doi":"10.1158/2159-8290.cd-21-0999","title":"Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis","year":2021,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Cancer, Stress, Anesthesia, and Immune Response","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Hotel Dieu Hospital","funders":"Labex Immuno-Oncology; High-end Foreign Experts Recruitment Plan of China; Royal Holloway, University of London; European Research Area Network on Cardiovascular Diseases; Fondation Gustave Roussy; Institut Universitaire de France; Centre National de la Recherche Scientifique; Ligue Contre le Cancer; Agence Nationale de la Recherche; Fondation ARC pour la Recherche sur le Cancer; Fondation pour la Recherche Médicale; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; E-Rare; Fondation Philanthropia; Association pour la Recherche sur le Cancer; Seerave Foundation; Institut Gustave-Roussy; Fondation Leducq; European Commission","keywords":"Dysbiosis; Carcinogenesis; Cancer; Receptor; Inflammation; Gut flora","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001574249,0.0003491766,0.0006504958,0.0002072595,0.0002381592,0.0001887319,0.000127217,0.0001431405,0.0001691286],"category_scores_gemma":[0.0001619798,0.0003086857,0.0001604208,0.000480604,0.0000981987,0.0002644915,0.0001105152,0.0002174391,0.000004870825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005731608,"about_ca_system_score_gemma":0.0008512108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001946945,"about_ca_topic_score_gemma":0.001053843,"domain_scores_codex":[0.9979588,0.00011575,0.0003128519,0.0007101776,0.000363745,0.0005386996],"domain_scores_gemma":[0.9989059,0.0001875208,0.0001400983,0.0003968483,0.0001387611,0.0002308545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002393278,0.0002905373,0.7774127,0.0008924818,0.0006254076,0.0002673441,0.003026354,0.0002048966,0.116114,0.0001080555,0.002128899,0.09653613],"study_design_scores_gemma":[0.001608756,0.0002145299,0.2412941,0.003607359,0.0003758025,0.00004349682,0.002691437,0.00002597668,0.7416987,0.00001229676,0.007995485,0.0004320974],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9486263,0.04658444,0.00001535182,0.002797548,0.001073183,0.0004301121,0.00018096,0.00005424833,0.0002378623],"genre_scores_gemma":[0.9845718,0.01134886,0.00002551377,0.001312988,0.0007105839,0.000399775,0.00004202889,0.00006189304,0.001526614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6255847,"threshold_uncertainty_score":0.9999365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0239791325535012,"score_gpt":0.2841271438694557,"score_spread":0.2601480113159545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}