{"id":"W4200119638","doi":"10.1158/2159-8290.cd-21-0999","title":"Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis","year":2021,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Cancer, Stress, Anesthesia, and Immune Response","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Hotel Dieu Hospital","funders":"Labex Immuno-Oncology; High-end Foreign Experts Recruitment Plan of China; Royal Holloway, University of London; European Research Area Network on Cardiovascular Diseases; Fondation Gustave Roussy; Institut Universitaire de France; Centre National de la Recherche Scientifique; Ligue Contre le Cancer; Agence Nationale de la Recherche; Fondation ARC pour la Recherche sur le Cancer; Fondation pour la Recherche Médicale; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; E-Rare; Fondation Philanthropia; Association pour la Recherche sur le Cancer; Seerave Foundation; Institut Gustave-Roussy; Fondation Leducq; European Commission","keywords":"Dysbiosis; Carcinogenesis; Cancer; Receptor; Inflammation; Gut flora","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001167762,0.0001769942,0.0002212153,0.0001360382,0.0001318741,0.0003427277,0.00009670169,0.000227654,0.001126832],"category_scores_gemma":[0.00008545921,0.00008142788,0.0001751676,0.0001006169,0.0002308203,0.0001730941,0.0002412167,0.0006235788,0.0001793073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002223508,"about_ca_system_score_gemma":0.0001909979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002034454,"about_ca_topic_score_gemma":0.0004694395,"domain_scores_codex":[0.9999031,0.00001466,0.000005760841,0.00001452668,0.00002748556,0.00003442537],"domain_scores_gemma":[0.9999181,0.00001180962,0.00003149708,0.00000669619,0.000007592974,0.00002434516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004076282,0.00006125934,0.002601731,0.0000947691,0.00001065741,0.0002806468,0.00002839526,0.00004396393,0.9853697,0.0003664276,0.0002955628,0.01043924],"study_design_scores_gemma":[0.00006611798,0.003156646,0.1844066,0.00008674284,0.0001119038,0.005605087,0.0004187539,0.00113881,0.783788,0.0007531862,0.02043919,0.0000289312],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780549,0.01462126,0.002411815,0.0009508057,0.0001457933,0.00003258459,0.0001622254,0.0001144886,0.00350615],"genre_scores_gemma":[0.9885631,0.007795113,0.0008980291,0.0002195018,0.00005701406,0.00001767423,0.000111299,0.000008971243,0.00232934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001126832,"threshold_uncertainty_score":0.003769636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0239791325535012,"score_gpt":0.2841271438694557,"score_spread":0.2601480113159545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}