{"id":"W4200128001","doi":"10.1101/2021.12.01.470637","title":"Transcription feedback dynamics in the wake of cytoplasmic degradation shutdown","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation; Israel Science Foundation","keywords":"Messenger RNA; Cell biology; Transcription (linguistics); Exonuclease; RNA; Nonsense-mediated decay; Biology; Chemistry; RNA splicing; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001217554,0.0001400385,0.0003469305,0.0001453927,0.0001392376,0.0004147016,0.0001661422,0.0002142547,0.001640797],"category_scores_gemma":[0.0003181806,0.0001215381,0.0001282769,0.0001057336,0.0002463115,0.0002624379,0.0002252584,0.0005047322,0.0004031509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004259865,"about_ca_system_score_gemma":0.000186934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008123411,"about_ca_topic_score_gemma":0.0006627482,"domain_scores_codex":[0.9999074,0.000006407952,0.000003583945,0.00002936558,0.0000338499,0.00001944786],"domain_scores_gemma":[0.9998291,0.00003705323,0.00003322916,0.00001734191,0.00004095502,0.00004223146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002796146,0.00002203004,0.002513421,0.00003301032,0.000008026162,0.0002777545,0.00008436559,0.000984798,0.9917915,0.0004388806,0.0002105072,0.003356102],"study_design_scores_gemma":[0.00003657756,0.0003073436,0.07011385,0.00001986704,0.00001856261,0.000302878,0.0002916825,0.03729521,0.8853177,0.001522208,0.004741508,0.00003258597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935416,0.000818721,0.003650057,0.0001742488,0.00004576211,0.000007677167,0.0002694343,0.0002428596,0.001249619],"genre_scores_gemma":[0.9983904,0.00009077037,0.0004123446,0.00003451493,0.000007989319,0.000006178061,0.0001794357,0.00002085112,0.0008575079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001640797,"threshold_uncertainty_score":0.005488992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01230496615117148,"score_gpt":0.2286926451772735,"score_spread":0.216387679026102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}