{"id":"W4200135346","doi":"10.1016/s0140-6736(21)02753-7","title":"Final efficacy analysis, interim safety analysis, and immunogenicity of a single dose of recombinant novel coronavirus vaccine (adenovirus type 5 vector) in adults 18 years and older: an international, multicentre, randomised, double-blinded, placebo-controlled phase 3 trial","year":2021,"lang":"en","type":"article","venue":"The Lancet","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":237,"is_retracted":false,"has_abstract":false,"ca_institutions":"Nova Scotia Health Authority; Dalhousie University","funders":"Beijing Institute of Technology","keywords":"Immunogenicity; Interim; Interim analysis; Virology; Medicine; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Recombinant DNA; Vector (molecular biology); 2019-20 coronavirus outbreak; Clinical trial; Immunology; Internal medicine; Biology; Immune system; Outbreak; Geography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005012414,0.002236643,0.004374008,0.0004376063,0.0006093014,0.001542959,0.0008349196,0.002871797,0.00541439],"category_scores_gemma":[0.004729496,0.0007649431,0.004200161,0.0004378817,0.001281683,0.001466862,0.0004149038,0.003357067,0.0009320986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007576622,"about_ca_system_score_gemma":0.001265024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004722151,"about_ca_topic_score_gemma":0.0006135008,"domain_scores_codex":[0.9982077,0.0009209447,0.0001600049,0.0002792625,0.0001569877,0.0002750418],"domain_scores_gemma":[0.9973825,0.0009511997,0.0006378649,0.000297969,0.0002963457,0.0004342131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9895386,0.001524014,0.0003162596,0.0003466559,0.0007744087,0.0000178946,0.00003145195,0.0002062049,0.001408068,0.00007247741,0.0003481226,0.005415892],"study_design_scores_gemma":[0.8888352,0.105308,0.002374612,0.00005118042,0.001188231,0.00003042098,0.00002047991,0.0003901989,0.0007683417,0.0003007085,0.0007070911,0.00002553939],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97092,0.007750957,0.003960312,0.0007057482,0.001059337,0.00930772,0.002518471,0.0002177616,0.003559676],"genre_scores_gemma":[0.9787343,0.001922663,0.003062778,0.001161233,0.0005018734,0.01005463,0.001690376,0.0000566356,0.002815568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00541439,"threshold_uncertainty_score":0.02650845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06440356679023261,"score_gpt":0.3733364001359493,"score_spread":0.3089328333457166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}