{"id":"W4200135346","doi":"10.1016/s0140-6736(21)02753-7","title":"Final efficacy analysis, interim safety analysis, and immunogenicity of a single dose of recombinant novel coronavirus vaccine (adenovirus type 5 vector) in adults 18 years and older: an international, multicentre, randomised, double-blinded, placebo-controlled phase 3 trial","year":2021,"lang":"en","type":"article","venue":"The Lancet","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":237,"is_retracted":false,"has_abstract":false,"ca_institutions":"Nova Scotia Health Authority; Dalhousie University","funders":"Beijing Institute of Technology","keywords":"Immunogenicity; Interim; Interim analysis; Virology; Medicine; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Recombinant DNA; Vector (molecular biology); 2019-20 coronavirus outbreak; Clinical trial; Immunology; Internal medicine; Biology; Immune system; Outbreak; Geography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009288007,0.0001649778,0.0008743154,0.0001880803,0.00003606952,0.00003100363,0.0003280236,0.0001014192,0.0001203152],"category_scores_gemma":[0.0002152766,0.0001319873,0.0002097463,0.0005834551,0.00008491469,0.00001143005,0.0001584196,0.0001446907,4.974601e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002667674,"about_ca_system_score_gemma":0.00009952764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003420945,"about_ca_topic_score_gemma":0.002625849,"domain_scores_codex":[0.9983073,0.000313163,0.000568365,0.0003806504,0.0002074705,0.0002229864],"domain_scores_gemma":[0.9987556,0.0001353438,0.0002736305,0.0005865344,0.00018681,0.00006208019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6337678,0.0009928425,0.001343726,0.00001112745,0.002295677,0.000004674661,0.0001684749,0.0001735314,0.3590993,0.000002712708,0.000006194726,0.002133947],"study_design_scores_gemma":[0.8615038,0.002195477,0.02159599,0.00003197145,0.0009243779,0.000004787702,0.0000929586,0.001663547,0.1116968,0.000002918971,0.0001245931,0.0001627638],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965934,0.00222896,0.00009545932,0.00009054618,0.0001033349,0.000759822,0.00009676829,0.000004580785,0.00002714399],"genre_scores_gemma":[0.9972556,0.002076361,0.0001387509,0.00003641303,0.0001080348,0.00002179113,0.0003085985,0.00001304412,0.00004143742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2474025,"threshold_uncertainty_score":0.5382285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06440356679023261,"score_gpt":0.3733364001359493,"score_spread":0.3089328333457166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}