{"id":"W4200135433","doi":"10.1093/ofid/ofab466.1247","title":"1053. The β-Lactamase Inhibitor QPX7728 Restores the Activity of β-Lactam Agents against Contemporary Extended-Spectrum β-lactamase (ESBL)-Producing and Carbapenem-Resistant <i>Enterobacterales</i> (CRE) Isolates, Including Isolates Producing Metallo-β-lactamases","year":2021,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Aztreonam; Meropenem; Broth microdilution; Cefepime; Microbiology; Tazobactam; Avibactam; Carbapenem; Piperacillin/tazobactam; Klebsiella pneumoniae; Piperacillin; Medicine; Biology; Antibiotics; Imipenem; Bacteria; Escherichia coli; Minimum inhibitory concentration; Pseudomonas aeruginosa; Antibiotic resistance; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001217236,0.0003314375,0.000307267,0.0001648943,0.00009319693,0.0003123123,0.0002456736,0.0002668994,0.005094779],"category_scores_gemma":[0.0002684206,0.0001082297,0.0002149519,0.0001068709,0.0001897299,0.000195991,0.0001879909,0.0004490669,0.0007222955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001949531,"about_ca_system_score_gemma":0.0002924092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001063831,"about_ca_topic_score_gemma":0.0008092842,"domain_scores_codex":[0.9998028,0.0000428755,0.00001713537,0.00003360959,0.00005114597,0.00005247708],"domain_scores_gemma":[0.9998639,0.0000430068,0.00002012768,0.00001352719,0.00001975823,0.00003964463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00164892,0.001237992,0.003667844,0.0001583841,0.00003443562,0.0002561415,0.00003528194,0.0002800524,0.9686739,0.0001777511,0.0008374834,0.02299185],"study_design_scores_gemma":[0.0005918588,0.01777877,0.04087295,0.0000419458,0.00008864916,0.00124075,0.00008344991,0.003735056,0.9290284,0.00008988063,0.00643338,0.00001498844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964491,0.0006214898,0.0003441017,0.00007909314,0.00002988497,0.00005429764,0.0004363323,0.00004738563,0.001938233],"genre_scores_gemma":[0.9934083,0.0004159977,0.001256368,0.00007828032,0.00002514296,0.00003634781,0.002575603,0.00001572052,0.002188291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005094779,"threshold_uncertainty_score":0.01704371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01831730207634226,"score_gpt":0.2674577305797025,"score_spread":0.2491404285033603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}