{"id":"W4200137491","doi":"10.1182/blood.2021014559","title":"Suppression of fibrin(ogen)-driven pathologies in disease models through controlled knockdown by lipid nanoparticle delivery of siRNA","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Dental and Craniofacial Research; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"Fibrinogen; Fibrin; Platelet; Coagulation; Immunology; Ex vivo; In vivo; Hemostasis; Chemistry; Proinflammatory cytokine; Immune system; Gene knockdown; Medicine; Inflammation; Pharmacology; Cancer research; Internal medicine; Biology; Apoptosis; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002809064,0.0005629747,0.0003049565,0.0002606063,0.0001229864,0.0002824102,0.0001839555,0.0003833981,0.0005972369],"category_scores_gemma":[0.0001032435,0.0001333087,0.000337659,0.0001242806,0.0002495714,0.0001822562,0.0001701295,0.0005216487,0.0002712332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002372416,"about_ca_system_score_gemma":0.0001806091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003785174,"about_ca_topic_score_gemma":0.0007531823,"domain_scores_codex":[0.9998166,0.00002819743,0.00002614188,0.00005063345,0.00004297328,0.00003548968],"domain_scores_gemma":[0.9999381,0.0000101065,0.00002628687,0.000006265534,0.000008905891,0.00001024084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000449322,0.00001482529,0.0000376271,0.00003582963,0.000004788573,0.00002429608,0.0000104571,0.00004564609,0.9987307,0.00006990312,0.00003436654,0.0009465702],"study_design_scores_gemma":[0.00001573224,0.0003697136,0.0006215045,0.000004749068,0.000022248,0.0001036146,0.000008253419,0.0008181903,0.9959443,0.00002992286,0.002058243,0.000003578333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9471803,0.004780539,0.04309065,0.0003005755,0.0001578502,0.0002192101,0.0008031782,0.0006011756,0.002866523],"genre_scores_gemma":[0.9739383,0.002948706,0.01685757,0.0001578565,0.00002532925,0.000313023,0.0007001923,0.00006851413,0.004990519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005972369,"threshold_uncertainty_score":0.001997948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01641546061555888,"score_gpt":0.2488801387148349,"score_spread":0.232464678099276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}