{"id":"W4200141214","doi":"10.3390/ijms222413224","title":"Nicotinamide Mononucleotide Prevents Free Fatty Acid-Induced Reduction in Glucose Tolerance by Decreasing Insulin Clearance","year":2021,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health; University of Toronto","keywords":"Nicotinamide mononucleotide; Endocrinology; Internal medicine; NAD+ kinase; Chemistry; Insulin; Nicotinamide; Intracellular; Butyrate; Nicotinamide phosphoribosyltransferase; Biochemistry; Nicotinamide adenine dinucleotide; Biology; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001949618,0.0003882961,0.0004308554,0.0002587321,0.0001051455,0.0002283477,0.0002966489,0.000422553,0.001173313],"category_scores_gemma":[0.0001153633,0.0001209077,0.0002498825,0.0001446279,0.0002416029,0.0001988759,0.000170046,0.0008097165,0.0002121013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002009124,"about_ca_system_score_gemma":0.0002739974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004387002,"about_ca_topic_score_gemma":0.001452121,"domain_scores_codex":[0.9998711,0.00003479797,0.00001277693,0.00002996665,0.0000273568,0.00002395026],"domain_scores_gemma":[0.9999107,0.000007032783,0.00002745286,0.00001353281,0.00001175908,0.00002946386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002036466,0.000192841,0.0004423242,0.00009849319,0.00002556014,0.00004509648,0.00001573941,0.00005289542,0.9909923,0.0001487562,0.00007236982,0.005877221],"study_design_scores_gemma":[0.0001652095,0.003953915,0.006873636,0.00002631628,0.00007116713,0.0001601746,0.00004625813,0.0007052262,0.9835454,0.0001539939,0.004289102,0.000009659959],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872369,0.006719205,0.003546837,0.0002628471,0.0001524035,0.00004314999,0.0002852107,0.0001720219,0.001581528],"genre_scores_gemma":[0.9907182,0.003058251,0.003010176,0.0001418921,0.00003466757,0.00004832888,0.0003254421,0.00002644262,0.002636603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001173313,"threshold_uncertainty_score":0.003925145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01476685692665486,"score_gpt":0.3011620979664129,"score_spread":0.286395241039758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}