{"id":"W4200147207","doi":"10.1038/s41421-021-00344-4","title":"Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2","year":2021,"lang":"en","type":"article","venue":"Cell Discovery","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Canada Research Chairs; University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Genentech; Institut National Du Cancer; Fondation ARC pour la Recherche sur le Cancer; Wellcome Trust; Agence Nationale de la Recherche; Novartis Pharma; Ontario Genomics Institute; National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; National Institutes of Health; U.S. Department of Health and Human Services; Ontario Genomics; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Institut pour la Recherche en Santé Publique; McGill University; University of Chicago; Pfizer","keywords":"Histone; Lysine; Epigenome; SIRT2; Histone methyltransferase; Histone code; Acetylation; Histone H2A; Biochemistry; Histone H3; Chemistry; Biology; Sirtuin; Gene; Gene expression; Amino acid; Nucleosome; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001266467,0.0001566011,0.0002658704,0.00008779958,0.00008868859,0.00003738831,0.000037577,0.0001295301,0.0002437864],"category_scores_gemma":[0.00004514475,0.0001331331,0.00008051925,0.0002349638,0.0001023928,0.0002204035,0.00001780993,0.0001647885,0.00001302378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006652666,"about_ca_system_score_gemma":0.0001460794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004386323,"about_ca_topic_score_gemma":0.000007152115,"domain_scores_codex":[0.9988071,0.00004333219,0.000286416,0.0003654363,0.0003296431,0.0001681248],"domain_scores_gemma":[0.99927,0.00005897741,0.00008541578,0.0002865426,0.00019196,0.0001070545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001889768,0.0002389682,0.0009683893,0.0001358092,0.00007266491,0.00003247409,0.0004566829,0.00004730993,0.9901444,0.0001548854,0.0037863,0.003773195],"study_design_scores_gemma":[0.0199122,0.001093369,0.3633775,0.0007526458,0.002308654,0.0005972682,0.002468426,0.1091072,0.4546972,0.002066608,0.04214526,0.001473657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9712058,0.01140269,0.006396684,0.008718706,0.0001886545,0.0002298615,0.00007327374,0.00004076202,0.00174352],"genre_scores_gemma":[0.9730588,0.0007341523,0.0008036462,0.001239685,0.00009096513,0.000008596439,0.00201453,0.00002605505,0.02202356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5354471,"threshold_uncertainty_score":0.542901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008278357916250395,"score_gpt":0.2772793413441487,"score_spread":0.2690009834278982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}