{"id":"W4200147207","doi":"10.1038/s41421-021-00344-4","title":"Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2","year":2021,"lang":"en","type":"article","venue":"Cell Discovery","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Canada Research Chairs; University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Genentech; Institut National Du Cancer; Fondation ARC pour la Recherche sur le Cancer; Wellcome Trust; Agence Nationale de la Recherche; Novartis Pharma; Ontario Genomics Institute; National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; National Institutes of Health; U.S. Department of Health and Human Services; Ontario Genomics; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Institut pour la Recherche en Santé Publique; McGill University; University of Chicago; Pfizer","keywords":"Histone; Lysine; Epigenome; SIRT2; Histone methyltransferase; Histone code; Acetylation; Histone H2A; Biochemistry; Histone H3; Chemistry; Biology; Sirtuin; Gene; Gene expression; Amino acid; Nucleosome; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001507925,0.0003317976,0.0002475164,0.0002128736,0.0001836458,0.0002855729,0.0001808397,0.000244057,0.001775497],"category_scores_gemma":[0.0001171834,0.0001621032,0.0003881329,0.0002004161,0.0001895626,0.0002328828,0.000191214,0.0003673913,0.0005440615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002298062,"about_ca_system_score_gemma":0.0001469593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005506615,"about_ca_topic_score_gemma":0.001217528,"domain_scores_codex":[0.9998792,0.00001250232,0.00000643079,0.00004737539,0.00003160294,0.00002288315],"domain_scores_gemma":[0.9998844,0.00001118284,0.00004956059,0.00001453837,0.00002022287,0.00002007199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007635237,0.000005466739,0.001424052,0.00004007178,0.00001337399,0.0000506096,0.00001380662,0.00002564877,0.9955608,0.00009206358,0.0000469441,0.002650823],"study_design_scores_gemma":[0.00000719173,0.0001318508,0.04218732,0.00000671977,0.00003304021,0.0004819227,0.00005454506,0.0003865123,0.950902,0.000124652,0.005672855,0.0000115061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9693359,0.009919249,0.01433366,0.0003198514,0.0001062189,0.00003557583,0.0008922371,0.0002631786,0.004794075],"genre_scores_gemma":[0.9883273,0.002098636,0.004071509,0.0001162104,0.00003049177,0.00001286167,0.0009956869,0.00002999002,0.004317243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001775497,"threshold_uncertainty_score":0.005939662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008278357916250395,"score_gpt":0.2772793413441487,"score_spread":0.2690009834278982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}