{"id":"W4200151232","doi":"10.1093/ofid/ofab466.021","title":"21. Efficacy and Safety of Maribavir as a Rescue Treatment for Investigator Assigned Therapy in Transplant Recipients With Refractory or Resistant Cytomegalovirus Infections in the SOLSTICE Study: Phase 3 Trial Results","year":2021,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Internal medicine; Foscarnet; Refractory (planetary science); Viremia; Transplantation; Ganciclovir; Valganciclovir; Neutropenia; Randomized controlled trial; Gastroenterology; Human cytomegalovirus; Surgery; Immunology; Chemotherapy; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008747489,0.0003408662,0.0008306716,0.0003422885,0.0003430873,0.0001927693,0.0002181706,0.000118554,0.00009013981],"category_scores_gemma":[0.00153433,0.0002031472,0.000127103,0.001000816,0.0001971949,0.0002643691,0.00008066276,0.0002760253,0.000003606761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003838233,"about_ca_system_score_gemma":0.00233065,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006289151,"about_ca_topic_score_gemma":0.0338043,"domain_scores_codex":[0.996826,0.000678939,0.0008234239,0.0006962271,0.0004769432,0.0004984678],"domain_scores_gemma":[0.997036,0.001550216,0.0001787892,0.0006902159,0.0001998222,0.0003449774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8398091,0.03967874,0.09627753,0.00008113926,0.0005763134,0.0008796443,0.002941949,0.00002448894,0.001243978,0.0001617063,0.0004940117,0.01783134],"study_design_scores_gemma":[0.6854123,0.1058296,0.1771885,0.0007611536,0.0006066458,0.0001351317,0.002605851,0.00005428498,0.0009758661,0.0001654413,0.02575594,0.0005092491],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864563,0.0003317925,0.000008422804,0.00095363,0.00008062003,0.0094854,0.0008493357,0.00002953327,0.001804971],"genre_scores_gemma":[0.9958782,0.001141344,0.00003208284,0.0003589056,0.00006172383,0.001797313,0.0002138744,0.00004687442,0.0004696951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1543968,"threshold_uncertainty_score":0.9838263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05810295756625286,"score_gpt":0.382947389499344,"score_spread":0.3248444319330912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}