{"id":"W4200151232","doi":"10.1093/ofid/ofab466.021","title":"21. Efficacy and Safety of Maribavir as a Rescue Treatment for Investigator Assigned Therapy in Transplant Recipients With Refractory or Resistant Cytomegalovirus Infections in the SOLSTICE Study: Phase 3 Trial Results","year":2021,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Internal medicine; Foscarnet; Refractory (planetary science); Viremia; Transplantation; Ganciclovir; Valganciclovir; Neutropenia; Randomized controlled trial; Gastroenterology; Human cytomegalovirus; Surgery; Immunology; Chemotherapy; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002086189,0.0009134015,0.001599896,0.0002738352,0.0003120405,0.0009018639,0.0006324195,0.001082032,0.003778146],"category_scores_gemma":[0.001099423,0.0003284709,0.001741,0.000193358,0.0007182299,0.0006186813,0.0003095135,0.00238333,0.0007911597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004986181,"about_ca_system_score_gemma":0.00118292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004707279,"about_ca_topic_score_gemma":0.001616332,"domain_scores_codex":[0.9994653,0.0003272772,0.00003046859,0.00006242182,0.00003471084,0.00007988045],"domain_scores_gemma":[0.9994597,0.00009022753,0.0001033041,0.00004924574,0.0000376616,0.0002599176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9377175,0.0105738,0.003293816,0.0005725194,0.0009474086,0.00007616494,0.000108615,0.0006112936,0.01257178,0.000144693,0.001471231,0.03191122],"study_design_scores_gemma":[0.8167567,0.1723747,0.006171041,0.00006147126,0.0006440934,0.00007073126,0.00003498217,0.0008001738,0.001656047,0.000208742,0.001198298,0.00002294926],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925733,0.002126744,0.0002767184,0.0005729502,0.0001622325,0.001649317,0.0008602301,0.00008123798,0.001697189],"genre_scores_gemma":[0.9923768,0.0009229832,0.0011465,0.0006564982,0.0001547556,0.001813478,0.001032635,0.00001955157,0.00187685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003778146,"threshold_uncertainty_score":0.01263922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05810295756625286,"score_gpt":0.382947389499344,"score_spread":0.3248444319330912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}