{"id":"W4200152005","doi":"10.1016/j.mcpro.2021.100182","title":"Immune Checkpoint Blockade Augments Changes Within Oncolytic Virus-induced Cancer MHC-I Peptidome, Creating Novel Antitumor CD8 T Cell Reactivities","year":2021,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Prince Edward Island; Dalhousie University","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Dalhousie University; National Institutes of Health; Eberhard Karls Universität Tübingen; Dalhousie Medical Research Foundation","keywords":"Oncolytic virus; CD8; MHC class I; Immunotherapy; Cytotoxic T cell; Major histocompatibility complex; Immune checkpoint; T cell; Cancer research; Epitope; Cancer immunotherapy; Immune system; Immunology; Biology; Cancer; Antigen; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005611835,0.0002464362,0.0001406221,0.00009641285,0.00005208973,0.0001875936,0.00008794812,0.0001659582,0.0006496301],"category_scores_gemma":[0.00005583539,0.00008515627,0.0001322554,0.00005742603,0.0001008299,0.0001384835,0.0001099112,0.0003915454,0.0001414913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001502502,"about_ca_system_score_gemma":0.0000836891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001400828,"about_ca_topic_score_gemma":0.0002424928,"domain_scores_codex":[0.9999337,0.000006766414,0.000004244429,0.00001714536,0.00001659416,0.00002146952],"domain_scores_gemma":[0.9999733,0.000003566464,0.00001081533,0.00000272544,0.000002735416,0.00000687898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002678165,0.000007263346,0.00004742357,0.000008795122,0.000001382192,0.00000547344,0.000002190854,0.00003405231,0.999436,0.00001641126,0.000005400065,0.0004087628],"study_design_scores_gemma":[0.00000484937,0.000162516,0.001293683,0.000001784763,0.000005177021,0.00007531627,0.000006559477,0.000611822,0.9972593,0.00001513846,0.0005623734,0.000001431494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967044,0.0006664454,0.001813112,0.00002574432,0.00001149364,0.00001677634,0.00009302504,0.00002959753,0.00063937],"genre_scores_gemma":[0.9968257,0.0004096955,0.001810986,0.00002943611,0.000004954725,0.00002029176,0.0001536439,0.00001047942,0.0007348147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006496301,"threshold_uncertainty_score":0.002173245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02131380268545285,"score_gpt":0.2783175175943758,"score_spread":0.257003714908923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}