{"id":"W4200152005","doi":"10.1016/j.mcpro.2021.100182","title":"Immune Checkpoint Blockade Augments Changes Within Oncolytic Virus-induced Cancer MHC-I Peptidome, Creating Novel Antitumor CD8 T Cell Reactivities","year":2021,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Prince Edward Island; Dalhousie University","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Dalhousie University; National Institutes of Health; Eberhard Karls Universität Tübingen; Dalhousie Medical Research Foundation","keywords":"Oncolytic virus; CD8; MHC class I; Immunotherapy; Cytotoxic T cell; Major histocompatibility complex; Immune checkpoint; T cell; Cancer research; Epitope; Cancer immunotherapy; Immune system; Immunology; Biology; Cancer; Antigen; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000711468,0.0005992473,0.0005615507,0.0001515242,0.0003222489,0.000176522,0.0005815292,0.0003929454,0.0001065213],"category_scores_gemma":[0.0001768373,0.000662273,0.000325271,0.0003942068,0.000155124,0.00001621165,0.0005585722,0.000582416,0.00003139026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002193455,"about_ca_system_score_gemma":0.0009456423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004150694,"about_ca_topic_score_gemma":0.0006462902,"domain_scores_codex":[0.9963635,0.0002856248,0.00061149,0.001142941,0.0006690683,0.0009273372],"domain_scores_gemma":[0.9977274,0.00002152884,0.0003940146,0.001251731,0.0003413848,0.0002639283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006823278,0.0004494823,0.00006589031,0.0001567763,0.0002671049,0.0002146737,0.000316612,0.0006340202,0.9967882,0.00001178176,0.00001483061,0.0003983249],"study_design_scores_gemma":[0.002129194,0.001186994,0.00002999799,0.0001180898,0.00008752075,0.00004116053,0.0003403919,0.0007266678,0.9938473,0.00003181693,0.0007195225,0.0007413652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914163,0.00361976,0.002093219,0.0003370782,0.0002802746,0.001175829,0.0001104108,0.0000529035,0.0009142775],"genre_scores_gemma":[0.9912193,0.0005089573,0.003866846,0.0003448327,0.0003913061,0.0005018712,0.0003454343,0.0002152478,0.002606175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003110803,"threshold_uncertainty_score":0.9995828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02131380268545285,"score_gpt":0.2783175175943758,"score_spread":0.257003714908923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}