{"id":"W4200157699","doi":"10.1101/2021.11.04.21265941","title":"Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer disease brains","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Instituto de Salud Carlos III; Canadian Institutes of Health Research; Deutsches Zentrum für Neurodegenerative Erkrankungen; National Institute of Neurological Disorders and Stroke; Korea Health Industry Development Institute; National Institute on Aging; Alzheimer's Association; Hope Center for Neurological Disorders; Japan Agency for Medical Research and Development; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis; Fondation Brain Canada; Biogen; Chan Zuckerberg Initiative; Vanderbilt University; Fleni; Eisai","keywords":"Metabolomics; Metabolome; PSEN1; Disease; TREM2; Lipidomics; Biology; Genetics; Medicine; Internal medicine; Bioinformatics; Alzheimer's disease; Presenilin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002531185,0.0003660505,0.0003349105,0.001347901,0.0002310786,0.0003949234,0.0001229751,0.000262527,0.001328734],"category_scores_gemma":[0.0004819506,0.0001339939,0.0002545852,0.0007221273,0.0001399186,0.0001763563,0.0004941803,0.0001893794,0.0001744851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001908978,"about_ca_system_score_gemma":0.0001092105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001885838,"about_ca_topic_score_gemma":0.002509066,"domain_scores_codex":[0.999905,0.00001921145,0.000008150527,0.000031039,0.0000196229,0.00001695151],"domain_scores_gemma":[0.9998295,0.0000289638,0.00006627611,0.00001501193,0.00003315071,0.00002707105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007784253,0.0002061949,0.6105298,0.0002800186,0.001115679,0.001645056,0.000620048,0.000772593,0.3439839,0.0002190415,0.001007499,0.03183593],"study_design_scores_gemma":[0.00002577562,0.0003111319,0.9886954,0.00001448576,0.0001427776,0.001126688,0.0002546871,0.000891261,0.007537578,0.0003496885,0.0006328582,0.00001768445],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970744,0.0005477082,0.0003538289,0.00004287598,0.000003277875,0.0000107448,0.00171385,0.00001666884,0.0002366036],"genre_scores_gemma":[0.9963877,0.0002496623,0.0008910954,0.00005161713,0.000006353881,0.00002240588,0.001993943,0.000008617141,0.0003885966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001885838,"threshold_uncertainty_score":0.004445076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02517315699645557,"score_gpt":0.3082977730510112,"score_spread":0.2831246160545557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}