{"id":"W4200157841","doi":"10.1016/j.tranon.2021.101318","title":"Chondroitin sulfate proteoglycan 4, a targetable oncoantigen that promotes ovarian cancer growth, invasion, cisplatin resistance and spheroid formation","year":2021,"lang":"en","type":"article","venue":"Translational Oncology","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Randy Shaver Cancer Research and Community Fund; University of Minnesota; National Natural Science Foundation of China; Minnesota Ovarian Cancer Alliance; Science and Technology Program of Hunan Province; American Cancer Society","keywords":"Cancer research; Cisplatin; Ovarian cancer; Medicine; Chondroitin sulfate proteoglycan; Cancer; Biology; Chemotherapy; Extracellular matrix; Internal medicine; Proteoglycan; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003739939,0.0002248874,0.0002875688,0.00006939813,0.0002473692,0.00005604642,0.0001761305,0.000287071,0.0004188334],"category_scores_gemma":[0.00009867923,0.0002234683,0.00008239849,0.0002357051,0.0001564164,0.00004202721,0.00007069732,0.0002308238,0.00001189213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005731814,"about_ca_system_score_gemma":0.0009128098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001355343,"about_ca_topic_score_gemma":0.005604292,"domain_scores_codex":[0.998088,0.0002298405,0.0003596701,0.0005522741,0.0003272787,0.000442955],"domain_scores_gemma":[0.9990586,0.00005001252,0.0001335315,0.0002446902,0.0003505629,0.0001625933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001032196,0.0002317954,0.0104379,0.0002711398,0.0001469532,0.00008846274,0.0004160493,0.00007123296,0.9671494,0.002767562,0.003459915,0.01392742],"study_design_scores_gemma":[0.003785687,0.0003880483,0.02592486,0.00009615457,0.0000498742,0.0001442984,0.0001244482,0.0004450849,0.7947281,0.004720001,0.1690554,0.0005380487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9425237,0.007330621,0.01987126,0.01564348,0.0002210582,0.001576138,0.0003633052,0.00004664606,0.01242376],"genre_scores_gemma":[0.9772065,0.0007816664,0.01487641,0.0004052005,0.0002623141,0.000368358,0.0007732426,0.00003945056,0.005286829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1724213,"threshold_uncertainty_score":0.9112773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02641675013668457,"score_gpt":0.2938679838096517,"score_spread":0.2674512336729671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}