{"id":"W4200161123","doi":"10.21203/rs.3.rs-1105540/v1","title":"Prime Editor-mediated Correction of a Pathogenic Mutation in Purebred Dogs","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Welichem Biotech (Canada)","funders":"Rural Development Administration","keywords":"Purebred; Mutation; Disease; Somatic cell; Labrador Retriever; Medicine; Biology; Genetics; Internal medicine; Pathology; Breed; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007653568,0.0003214188,0.000524986,0.0006710825,0.0002722416,0.0005320079,0.0003750737,0.0008626086,0.003406144],"category_scores_gemma":[0.000581694,0.0002349364,0.0003343885,0.0002125191,0.0005165359,0.0002315601,0.0005793264,0.0008004669,0.0006408255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001815361,"about_ca_system_score_gemma":0.0001965328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003573091,"about_ca_topic_score_gemma":0.000609239,"domain_scores_codex":[0.9992342,0.0001019526,0.00005992966,0.0003002493,0.0002163013,0.00008734612],"domain_scores_gemma":[0.9994498,0.0001971475,0.0001129423,0.0001153434,0.00005171411,0.00007300688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002236318,0.00005973524,0.0007700151,0.00008484026,0.00002185173,0.0007987046,0.00009014137,0.0001785676,0.990338,0.0005801259,0.0003414581,0.006512943],"study_design_scores_gemma":[0.00007906985,0.0010163,0.008800565,0.00002161936,0.00009365495,0.00619986,0.0001186482,0.002931064,0.9476564,0.0003357676,0.03271858,0.00002846694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9506488,0.0009144475,0.04003642,0.0002827393,0.0002737791,0.0002742113,0.002232504,0.001081423,0.004255594],"genre_scores_gemma":[0.957171,0.0006002594,0.02368535,0.0002558148,0.00004424497,0.000155556,0.002740677,0.0003899492,0.01495715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003406144,"threshold_uncertainty_score":0.01139468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01543658186233715,"score_gpt":0.3696651641579615,"score_spread":0.3542285822956243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}