{"id":"W4200161338","doi":"10.1016/j.jare.2021.12.009","title":"Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux","year":2021,"lang":"en","type":"article","venue":"Journal of Advanced Research","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Science Foundation of Hunan Province; National Natural Science Foundation of China","keywords":"Autophagy; Senescence; Metformin; Vascular smooth muscle; Autophagosome; Cell biology; Biology; Endocrinology; Internal medicine; Chemistry; Medicine; Apoptosis; Biochemistry; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001838113,0.0001497913,0.0004314763,0.0002010414,0.0001822624,0.00005350149,0.0002493435,0.00009457857,0.0006294692],"category_scores_gemma":[0.0007799195,0.0001175137,0.0002577267,0.0005816494,0.0001207998,0.0003437644,0.00009281524,0.0009542923,0.00003160739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001304971,"about_ca_system_score_gemma":0.0007733216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003813559,"about_ca_topic_score_gemma":7.477757e-7,"domain_scores_codex":[0.9969456,0.000365572,0.0005189952,0.0002569964,0.001377757,0.0005350899],"domain_scores_gemma":[0.9974274,0.0003307258,0.0001928722,0.0003937531,0.001228742,0.0004265188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001497839,0.0006589195,0.0001513686,0.0002677926,0.00008666066,0.001678544,0.0003551682,0.00003930379,0.9307822,0.00001841447,0.003941434,0.06187042],"study_design_scores_gemma":[0.002569142,0.0006941144,0.002546631,0.0003839969,0.00005483404,0.0001799038,0.001001797,0.0002238807,0.9090417,0.000570646,0.08260799,0.0001253495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9622195,0.03335665,0.0007329977,0.0007157274,0.0001795142,0.0002707828,0.000007975774,0.00002231449,0.002494536],"genre_scores_gemma":[0.9877315,0.004138779,0.00404096,0.0001597692,0.000318369,0.000008871628,0.0000129477,0.00004406008,0.00354471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07866655,"threshold_uncertainty_score":0.6892247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02703982862964504,"score_gpt":0.3596429055454097,"score_spread":0.3326030769157647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}