{"id":"W4200167174","doi":"10.1158/1535-7163.targ-21-p081","title":"Abstract P081: <i>In vitro</i> activity and efficacy of novel dual PARP-HDAC inhibitors","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"","keywords":"PARP inhibitor; Poly ADP ribose polymerase; DNA repair; Cancer research; Molecular biology; Synthetic lethality; Chemistry; Histone; Biology; Polymerase; DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000257635,0.000620114,0.0004569434,0.0002381599,0.000149826,0.000369506,0.0005037075,0.0003657873,0.004869157],"category_scores_gemma":[0.0001642849,0.0001529953,0.0002721842,0.0002601512,0.0001612958,0.0002811712,0.0001547669,0.00109618,0.001574285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004375196,"about_ca_system_score_gemma":0.000293527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000887541,"about_ca_topic_score_gemma":0.0009098216,"domain_scores_codex":[0.9998277,0.0000289777,0.00001997871,0.00003586735,0.00004770308,0.00003966763],"domain_scores_gemma":[0.9998777,0.00002323782,0.00003196849,0.00001254454,0.00002092657,0.000033599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001734086,0.0006177976,0.0004237737,0.0003624703,0.00004905801,0.00009383942,0.00002367407,0.0009562178,0.9790756,0.0002433046,0.003022109,0.01339812],"study_design_scores_gemma":[0.0002753249,0.005534411,0.002506368,0.00002423824,0.00007526145,0.0004430439,0.00001607113,0.002076933,0.9822164,0.00005289596,0.006766349,0.00001272139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9629173,0.01248098,0.00458242,0.000570209,0.0002687788,0.0002085436,0.005446769,0.0005830451,0.01294181],"genre_scores_gemma":[0.9806746,0.003726083,0.00307274,0.0002004362,0.00006719397,0.0001737583,0.005284691,0.0000681764,0.006732232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004869157,"threshold_uncertainty_score":0.016289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03704472708377646,"score_gpt":0.3269870545350563,"score_spread":0.2899423274512798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}