{"id":"W4200167894","doi":"10.1016/j.btre.2021.e00691","title":"Transcriptomic analysis of synchrony and productivity in self-cycling fermentation of engineered yeast producing shikimic acid","year":2021,"lang":"en","type":"article","venue":"Biotechnology Reports","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Shikimic acid; Fermentation; Saccharomyces cerevisiae; Transcriptome; Biology; Biochemistry; Yeast; Citric acid cycle; Metabolic pathway; Chemistry; Gene; Metabolism; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002656583,0.00009826083,0.0002702739,0.0002520188,0.00001333742,0.000002841106,0.00003715884,0.0002167491,0.000001905628],"category_scores_gemma":[0.0001569136,0.0001047129,0.00006041087,0.0005929268,0.00005477438,0.000004618674,0.00003169128,0.00008921308,4.858378e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001325041,"about_ca_system_score_gemma":0.00004871539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002806956,"about_ca_topic_score_gemma":0.00005513119,"domain_scores_codex":[0.9990333,0.00002547139,0.0003411235,0.000428818,0.00005475007,0.0001165447],"domain_scores_gemma":[0.9994003,8.309019e-7,0.0001491127,0.0003734124,0.00006130449,0.00001506689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001143864,0.00008273234,0.008250476,0.00008231133,0.0002520712,0.00000841056,0.00009119522,0.0005498116,0.9890584,0.00001004098,0.000003560077,0.001599519],"study_design_scores_gemma":[0.0001103924,0.00003595183,0.04874317,0.00001753232,0.0001942841,0.0001156829,0.00004325081,0.00008614655,0.9504412,0.000006150695,0.0001195626,0.00008670516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969485,0.001701367,0.0009214859,0.0001200879,0.0001522411,0.0001200128,0.000006693266,0.00002417294,0.000005469456],"genre_scores_gemma":[0.9972438,0.0003111651,0.002304878,0.000003092451,0.00003718779,0.000006255359,0.00006295715,0.000008752972,0.00002191152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04049269,"threshold_uncertainty_score":0.4270068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004100285784223715,"score_gpt":0.2091164408431185,"score_spread":0.2050161550588948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}