{"id":"W4200170456","doi":"10.1101/2021.12.16.472805","title":"The <i>677C&gt;T</i> variant in <i>methylenetetrahydrofolate reductase</i> causes morphological and functional cerebrovascular deficits in mice","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research; BrightFocus Foundation","keywords":"Methylenetetrahydrofolate reductase; Homocysteine; Endocrinology; Internal medicine; Medicine; Chemistry; Allele; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003964212,0.0009039656,0.0004800334,0.0009351622,0.0005147777,0.0006645927,0.0006882466,0.001426446,0.00486527],"category_scores_gemma":[0.000212867,0.0005869181,0.001202593,0.0003593646,0.0007886498,0.0002708898,0.0004005086,0.002189063,0.001920572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005781685,"about_ca_system_score_gemma":0.0004330408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003824847,"about_ca_topic_score_gemma":0.004011678,"domain_scores_codex":[0.9993136,0.00009811463,0.000110016,0.0001780475,0.000145292,0.0001548562],"domain_scores_gemma":[0.9993312,0.00005987538,0.0002780705,0.00008971933,0.00004625818,0.0001949757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005099063,0.0001948619,0.0004664007,0.00006785212,0.00005192059,0.0003410417,0.00004794991,0.0001766876,0.9961404,0.000454934,0.0004379532,0.001110116],"study_design_scores_gemma":[0.0003615381,0.001789818,0.01945453,0.0001378391,0.0003530361,0.002518875,0.0003055454,0.004920173,0.9515207,0.0006931268,0.01787082,0.00007402821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701325,0.001057365,0.01159801,0.001301531,0.0004333789,0.0001661876,0.008555435,0.00118257,0.005573011],"genre_scores_gemma":[0.9681938,0.00124712,0.006592195,0.0009362828,0.0001060169,0.0003039752,0.005123593,0.0007522698,0.01674465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00486527,"threshold_uncertainty_score":0.01627594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0206193703372591,"score_gpt":0.2386532562902712,"score_spread":0.2180338859530121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}