{"id":"W4200171924","doi":"10.3390/jdb10010001","title":"Loss of Planar Cell Polarity Effector Fuzzy Causes Renal Hypoplasia by Disrupting Several Signaling Pathways","year":2021,"lang":"en","type":"article","venue":"Journal of Developmental Biology","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada","keywords":"Cilium; Ureteric bud; Biology; Cell biology; Kidney development; Hypoplasia; Morphogenesis; Convergent extension; Ciliopathies; Wnt signaling pathway; Effector; Phenotype; Internal medicine; Endocrinology; Signal transduction; Genetics; Embryonic stem cell; Anatomy; Gastrulation; Gene; Medicine; Embryogenesis; Embryo","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009595489,0.0003387342,0.0001908951,0.0004570771,0.0001604841,0.0001832117,0.0002067502,0.0003474107,0.00112912],"category_scores_gemma":[0.0001258074,0.0002163307,0.0002347559,0.0001528862,0.0002981019,0.0001170713,0.000251804,0.000501423,0.000151165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002333251,"about_ca_system_score_gemma":0.000268583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000789913,"about_ca_topic_score_gemma":0.001402688,"domain_scores_codex":[0.9998335,0.00001984245,0.00001934749,0.00003348568,0.00006302394,0.00003076892],"domain_scores_gemma":[0.99986,0.00002373849,0.00004675901,0.00001250221,0.000006861841,0.00005000551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008363409,0.00002288196,0.0005095555,0.0000226656,0.000005899212,0.0002797268,0.00001101729,0.00009767731,0.9977992,0.00018405,0.00002541881,0.0009582008],"study_design_scores_gemma":[0.00002357812,0.000345201,0.01894297,0.00001135957,0.00003872407,0.003557673,0.00004707951,0.002008358,0.972472,0.0001472391,0.002395338,0.00001053068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965379,0.00044695,0.001904156,0.00004240762,0.000007791163,0.00001743275,0.0002607593,0.00008151823,0.0007010232],"genre_scores_gemma":[0.9960344,0.0003787942,0.001812272,0.00002611569,0.000003618165,0.00001500938,0.0002643355,0.00001650063,0.00144899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00112912,"threshold_uncertainty_score":0.003777266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007545836329559475,"score_gpt":0.2231415536363732,"score_spread":0.2155957173068137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}