{"id":"W4200172388","doi":"10.1158/1535-7163.targ-21-p200","title":"Abstract P200: Pre-clinical development of a dopamine receptor 2, PD-1 and CD47 trispecific antibody for treatment of small cell lung cancer","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Neuroendocrine Tumor Research Advances","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Biotechnology Research Institute","funders":"","keywords":"Lung cancer; Cancer; Antibody; Immunotherapy; Cancer research; Medicine; CD47; Immune system; Immunology; Receptor; Biology; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003964718,0.0004280299,0.0002538462,0.0003078417,0.0001758034,0.0003760734,0.0004247395,0.0006418221,0.004301242],"category_scores_gemma":[0.0001689623,0.0001656036,0.0003154372,0.0001247843,0.000142463,0.0002644443,0.000219599,0.001076335,0.001364552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004542674,"about_ca_system_score_gemma":0.0006032774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008828936,"about_ca_topic_score_gemma":0.001201012,"domain_scores_codex":[0.9998603,0.00002175094,0.000007023575,0.00001856337,0.00004505175,0.00004733863],"domain_scores_gemma":[0.9998647,0.00001393376,0.00001195496,0.00000915224,0.00003824487,0.00006197562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008995179,0.001931631,0.0008537754,0.0001913468,0.00004311962,0.0002780845,0.00005879213,0.0006214595,0.934089,0.0005907253,0.004848765,0.05559373],"study_design_scores_gemma":[0.001129673,0.0235646,0.006415509,0.00003325804,0.00009833361,0.001595667,0.00003279762,0.003079174,0.9141286,0.0002249224,0.04968105,0.00001636532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9265559,0.009001176,0.02552216,0.002003042,0.0005019344,0.002659773,0.002515659,0.0008243971,0.03041611],"genre_scores_gemma":[0.9570994,0.003423151,0.01303202,0.001060826,0.000122491,0.0007463681,0.00363922,0.00008297361,0.02079348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004301242,"threshold_uncertainty_score":0.0143891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06606885790911159,"score_gpt":0.4153148424151528,"score_spread":0.3492459845060412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}