{"id":"W4200172388","doi":"10.1158/1535-7163.targ-21-p200","title":"Abstract P200: Pre-clinical development of a dopamine receptor 2, PD-1 and CD47 trispecific antibody for treatment of small cell lung cancer","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Neuroendocrine Tumor Research Advances","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Biotechnology Research Institute","funders":"","keywords":"Lung cancer; Cancer; Antibody; Immunotherapy; Cancer research; Medicine; CD47; Immune system; Immunology; Receptor; Biology; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001133071,0.0002373373,0.0006524044,0.00008298614,0.00004308016,0.00001163256,0.00009735022,0.00003287341,0.0001492367],"category_scores_gemma":[0.00002619301,0.0002017457,0.0001771241,0.0001958871,0.0001282344,0.00002757681,0.00004180866,0.0001067955,7.589315e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001638615,"about_ca_system_score_gemma":0.0009760367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006280115,"about_ca_topic_score_gemma":0.00009822848,"domain_scores_codex":[0.998141,0.00006316575,0.0006720403,0.0004377568,0.0003237644,0.000362281],"domain_scores_gemma":[0.9987079,0.0001629623,0.0002410422,0.0003601158,0.0003674015,0.0001605614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001390826,0.00129407,0.02545899,0.001056132,0.0007501288,0.0001997514,0.0003346025,0.00003894614,0.8750758,0.000008239042,0.0000487073,0.09434386],"study_design_scores_gemma":[0.005292325,0.0007920248,0.01392576,0.0002101643,0.0003010496,0.00001892537,0.00009147844,0.0001818623,0.9106305,0.000008871305,0.06837444,0.0001726261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9512968,0.04485225,0.001895428,0.0004874564,0.0001826263,0.001074891,0.00008809363,0.00001803856,0.0001044027],"genre_scores_gemma":[0.9521342,0.02717435,0.01789707,0.0002359118,0.0001339381,0.0003472334,0.00008361756,0.00009109392,0.001902574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09417123,"threshold_uncertainty_score":0.8226953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06606885790911159,"score_gpt":0.4153148424151528,"score_spread":0.3492459845060412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}