{"id":"W4200177883","doi":"10.1038/s41559-021-01600-2","title":"Antigenic evolution can drive virulence evolution","year":2021,"lang":"en","type":"letter","venue":"Nature Ecology & Evolution","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Virulence; Hominidae; Evolutionary biology; Biology; Biological evolution; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.000424162,0.0008517473,0.0007124597,0.0004146713,0.0004764244,0.00005602423,0.0007597881,0.0092664,0.0001194575],"category_scores_gemma":[0.0005209571,0.0009772239,0.0005709775,0.0005861364,0.0003767021,0.00001624365,0.0004130831,0.004354388,0.0001374258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001684858,"about_ca_system_score_gemma":0.001789244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009487518,"about_ca_topic_score_gemma":0.002130972,"domain_scores_codex":[0.9947479,0.0007099126,0.0007661394,0.001888475,0.0006407353,0.001246776],"domain_scores_gemma":[0.996872,0.00005706344,0.0006268984,0.001347246,0.000925045,0.0001717677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006222378,0.0001182021,0.01229704,0.0001176675,0.0003347333,0.00007696446,0.00002123319,0.0008488686,0.04393704,0.0009861176,0.941112,0.00008787162],"study_design_scores_gemma":[0.002038311,0.0009380232,0.2683321,0.000194888,0.0006126323,0.0005578363,0.000153989,0.00434602,0.001550474,0.003386793,0.7152122,0.002676807],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.3702164,0.0750296,0.08588292,0.4240518,0.03088256,0.004602386,0.002480374,0.0008111019,0.006042897],"genre_scores_gemma":[0.8589937,0.0008014301,0.001019758,0.109321,0.007906598,0.0001500498,0.01273377,0.0001679041,0.008905752],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.4887773,"threshold_uncertainty_score":0.9992678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003134090711594796,"score_gpt":0.222976282935483,"score_spread":0.2198421922238882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}