{"id":"W4200182293","doi":"10.33594/000000477","title":"Phosphodiesterase 8A Regulates CFTR Activity in Airway Epithelial Cells","year":2021,"lang":"en","type":"article","venue":"Cellular Physiology and Biochemistry","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Université de Montréal; McGill University","keywords":"Cystic fibrosis transmembrane conductance regulator; Cystic fibrosis; Phosphodiesterase; Protein kinase A; Cell biology; Chloride channel; Phosphodiesterase 3; Intracellular; HEK 293 cells; Gene knockdown; Epithelial sodium channel; Cyclic adenosine monophosphate; Chemistry; Endocrinology; Internal medicine; Biology; Cell culture; Phosphorylation; Medicine; Biochemistry; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001650212,0.0002271386,0.0002583296,0.000151215,0.0002219033,0.0003585076,0.0002271189,0.0004418407,0.001600233],"category_scores_gemma":[0.0001478743,0.000119946,0.0003842038,0.0001157349,0.0002458291,0.000234051,0.0002678723,0.000679804,0.000731441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004734304,"about_ca_system_score_gemma":0.0001834096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005974717,"about_ca_topic_score_gemma":0.00078934,"domain_scores_codex":[0.9997975,0.00002726795,0.00002110724,0.00006032416,0.00005322589,0.00004050077],"domain_scores_gemma":[0.999899,0.00001843154,0.00002870923,0.00001289547,0.00002029291,0.0000205957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006124937,0.00001530086,0.0002163063,0.00004694407,0.00000347686,0.00003397338,0.00001028533,0.00003011661,0.9986877,0.00005044372,0.00008460697,0.0007597498],"study_design_scores_gemma":[0.00003686592,0.0002177793,0.0175224,0.00003325778,0.00003004619,0.0003450183,0.00009287141,0.00147215,0.9705933,0.0001392651,0.009506327,0.00001058732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788557,0.009231517,0.005825892,0.0007001485,0.0002046867,0.00006093184,0.001701607,0.000208163,0.003211361],"genre_scores_gemma":[0.9925044,0.002148056,0.002351371,0.0001874145,0.00002536328,0.00006195019,0.0008019853,0.00003035954,0.001889135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001600233,"threshold_uncertainty_score":0.005353332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005063949956221342,"score_gpt":0.2034438880293775,"score_spread":0.1983799380731562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}