{"id":"W4200182293","doi":"10.33594/000000477","title":"Phosphodiesterase 8A Regulates CFTR Activity in Airway Epithelial Cells","year":2021,"lang":"en","type":"article","venue":"Cellular Physiology and Biochemistry","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Université de Montréal; McGill University","keywords":"Cystic fibrosis transmembrane conductance regulator; Cystic fibrosis; Phosphodiesterase; Protein kinase A; Cell biology; Chloride channel; Phosphodiesterase 3; Intracellular; HEK 293 cells; Gene knockdown; Epithelial sodium channel; Cyclic adenosine monophosphate; Chemistry; Endocrinology; Internal medicine; Biology; Cell culture; Phosphorylation; Medicine; Biochemistry; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001067455,0.000225498,0.0002246426,0.00002333247,0.0001044374,0.00001927424,0.00009225585,0.0003673829,0.00007319704],"category_scores_gemma":[0.00003424914,0.0002181869,0.00009432798,0.0001044653,0.0002106423,0.000007255077,0.0001562965,0.0001632202,0.000009981697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001761168,"about_ca_system_score_gemma":0.00008962243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009055389,"about_ca_topic_score_gemma":0.000008916525,"domain_scores_codex":[0.9987676,0.00008689542,0.0001909601,0.0006027934,0.00007356871,0.0002782574],"domain_scores_gemma":[0.9993587,0.00002012001,0.00008065068,0.0003790754,0.00006742418,0.00009401103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000205094,0.0001380044,0.0004658298,0.00006970814,0.00003237671,0.00002334292,0.00002744397,0.00003399588,0.9976358,0.00001117323,0.0003489556,0.001008258],"study_design_scores_gemma":[0.0007567568,0.0000574712,0.003539997,0.00001831592,0.00001366729,0.0000254778,0.0000510541,0.00008907275,0.9914645,0.0001169563,0.003603242,0.0002635056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976422,0.001434454,0.000102149,0.0001263141,0.0002970842,0.00007869378,0.00002741615,0.00001605405,0.000275698],"genre_scores_gemma":[0.995551,0.0003423554,0.0001438984,0.0002336377,0.0002587708,0.00001416918,0.0003465785,0.00001735316,0.003092185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006171333,"threshold_uncertainty_score":0.8897403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005063949956221342,"score_gpt":0.2034438880293775,"score_spread":0.1983799380731562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}