{"id":"W4200185392","doi":"10.1016/j.annonc.2021.10.065","title":"48MO SQZ-PBMC-HPV-101: Preliminary results of a first-in-human, dose-escalation study of a cell-based vaccine in HLA A*02+ patients with recurrent, locally advanced, or metastatic HPV16+ solid tumors","year":2021,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Peripheral blood mononuclear cell; Antigen; Immune system; CD8; T cell; Regimen; Leukapheresis; Immunology; Oncology; Internal medicine; CD34","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001197019,0.0007521614,0.00134377,0.0002833609,0.0003908441,0.0006570331,0.0005097591,0.0008611095,0.002138798],"category_scores_gemma":[0.000778261,0.0003745451,0.0006373679,0.0002651105,0.0006603959,0.0005871673,0.0002781763,0.002213093,0.0005782678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004191294,"about_ca_system_score_gemma":0.000628719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008753964,"about_ca_topic_score_gemma":0.0009209505,"domain_scores_codex":[0.9995215,0.0002067061,0.00001843122,0.00006866943,0.00003893574,0.0001457492],"domain_scores_gemma":[0.9995046,0.000173626,0.00004635957,0.00007452164,0.00002390844,0.0001769638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2860089,0.1775625,0.02084291,0.000594236,0.0007924369,0.0007735433,0.00142496,0.006906017,0.3009181,0.0003664775,0.001981839,0.2018281],"study_design_scores_gemma":[0.04056312,0.909121,0.01903903,0.00001712915,0.0002784731,0.000372564,0.0001392558,0.001971073,0.02678077,0.0001158423,0.001583704,0.00001791808],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984347,0.0003466355,0.0002545466,0.00008494875,0.00003660956,0.0002769747,0.0001110432,0.00003411938,0.0004202268],"genre_scores_gemma":[0.9978589,0.0003367009,0.0004668728,0.0001178457,0.00005365106,0.0002158471,0.00027683,0.00001678852,0.0006564485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002138798,"threshold_uncertainty_score":0.007155001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03151643158945245,"score_gpt":0.3311245338745232,"score_spread":0.2996081022850708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}