{"id":"W4200190808","doi":"10.3390/molecules27010067","title":"Constrained Dipeptide Surrogates: 5- and 7-Hydroxy Indolizidin-2-one Amino Acid Synthesis from Iodolactonization of Dehydro-2,8-diamino Azelates","year":2021,"lang":"en","type":"article","venue":"Molecules","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Université de Montréal","keywords":"Chemistry; Dipeptide; Stereochemistry; Amino acid; Dihydroxylation; Serine; Isostere; Peptide; Intramolecular force; Diastereomer; Enantioselective synthesis; Organic chemistry; Catalysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001392379,0.0004667588,0.0002883317,0.0001556571,0.0000804849,0.0001966593,0.0003146611,0.0002940337,0.001642866],"category_scores_gemma":[0.0001474514,0.0001740232,0.0001647836,0.0002042822,0.0001084965,0.0002236939,0.0002528932,0.0004960993,0.0008700506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002656909,"about_ca_system_score_gemma":0.0002231935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002413253,"about_ca_topic_score_gemma":0.0006348154,"domain_scores_codex":[0.9998949,0.00001430401,0.000009188802,0.00002298962,0.00003176248,0.00002697661],"domain_scores_gemma":[0.9999046,0.000009385974,0.00002621639,0.000009572192,0.00001556937,0.00003459023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008848005,0.00001552831,0.00002871894,0.00005826464,0.000004875405,0.00008614635,0.00001480007,0.0002745572,0.9976214,0.0001737156,0.00003408947,0.001599389],"study_design_scores_gemma":[0.00002498211,0.0003827733,0.0002723007,0.000006501987,0.000008369059,0.000118535,0.00001002912,0.0005663416,0.9951258,0.00003608794,0.003439764,0.000008432592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731432,0.001725311,0.01763528,0.00006137846,0.00006410215,0.0002511362,0.0008659796,0.0001935029,0.006060123],"genre_scores_gemma":[0.9749855,0.001528752,0.01678592,0.00005690375,0.00001406494,0.000170644,0.0009951079,0.00007328521,0.005389765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001642866,"threshold_uncertainty_score":0.005495906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008746733074087503,"score_gpt":0.2074508867341826,"score_spread":0.1987041536600951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}