{"id":"W4200190918","doi":"10.1002/smll.202104632","title":"Design of Smart Size‐, Surface‐, and Shape‐Switching Nanoparticles to Improve Therapeutic Efficacy","year":2021,"lang":"en","type":"review","venue":"Small","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Photothermal therapy; Nanoparticle; Nanotechnology; Materials science; Rational design; Nanomedicine; Drug delivery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003804715,0.0008502877,0.0008135391,0.001087651,0.000148216,0.0005597019,0.0006152525,0.0008288797,0.001121316],"category_scores_gemma":[0.0001953127,0.0003497792,0.0004732019,0.0005988788,0.000276856,0.0009010843,0.0004336412,0.001051088,0.001057527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000457979,"about_ca_system_score_gemma":0.0004581063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003959855,"about_ca_topic_score_gemma":0.000634085,"domain_scores_codex":[0.9999142,0.00001225711,0.000006595349,0.00002047319,0.00002884271,0.00001774186],"domain_scores_gemma":[0.9999588,0.00001209057,0.000009830891,0.000002781827,0.00001163599,0.000004916887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008642572,0.0002368786,0.0001944653,0.01413018,0.0001111794,0.000418814,0.00009970446,0.002500922,0.2131879,0.02326154,0.01217295,0.733599],"study_design_scores_gemma":[0.00006010619,0.0005550775,0.001028863,0.001288006,0.0001765208,0.001682234,0.00005239871,0.002450316,0.09304161,0.0040275,0.8955721,0.00006525846],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007481205,0.9739014,0.009204449,0.0006491991,0.0005195683,0.0001109077,0.00009513026,0.0001040681,0.007934156],"genre_scores_gemma":[0.02676407,0.957646,0.00919094,0.000491481,0.0001595056,0.0001535158,0.0001473182,0.00001966524,0.00542758],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001121316,"threshold_uncertainty_score":0.003751159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0629863316822438,"score_gpt":0.2997459356462676,"score_spread":0.2367596039640238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}