{"id":"W4200201077","doi":"10.1016/j.humimm.2021.11.005","title":"Role of HLA molecular mismatch in clinical practice","year":2021,"lang":"en","type":"review","venue":"Human Immunology","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Manitoba Health; University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Human leukocyte antigen; Risk stratification; Clinical Practice; Categorization; Transplantation; Medicine; Biomarker; Intensive care medicine; Risk assessment; Computational biology; Computer science; Immunology; Internal medicine; Biology; Artificial intelligence; Family medicine; Antigen; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002657127,0.0008581149,0.002331084,0.002480153,0.0002678143,0.001817233,0.001000854,0.001905991,0.004783503],"category_scores_gemma":[0.006908803,0.000350719,0.0009158708,0.00269672,0.0008330454,0.002007063,0.001168271,0.002692451,0.0008514411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001733508,"about_ca_system_score_gemma":0.003517477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002059028,"about_ca_topic_score_gemma":0.004438493,"domain_scores_codex":[0.999083,0.0003231695,0.0001872557,0.0001407306,0.0002079537,0.00005787721],"domain_scores_gemma":[0.9959037,0.003050173,0.0004815262,0.00004875748,0.0003767558,0.0001391965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001316648,0.00004340031,0.0005179865,0.02770716,0.0002848618,0.0001059618,0.00005475948,0.0003561832,0.0001352702,0.00420648,0.03330955,0.9331468],"study_design_scores_gemma":[0.0001892282,0.0001734538,0.003141078,0.06464505,0.001802028,0.001104867,0.0001811534,0.0003558463,0.000161349,0.008964939,0.9192201,0.00006090965],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000332064,0.9986639,0.00004938824,0.0007139827,0.0002466694,0.000001644131,0.000007257417,0.000002293137,0.0002816365],"genre_scores_gemma":[0.0006285282,0.9977779,0.0001285316,0.000772142,0.0005598448,0.000005039697,0.0000124498,8.806675e-7,0.0001147124],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004783503,"threshold_uncertainty_score":0.01600242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07401202821497015,"score_gpt":0.4642905272557586,"score_spread":0.3902784990407884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}