{"id":"W4200201503","doi":"10.1101/2021.12.22.473918","title":"A novel zebrafish model of <i>SPEG</i> -related centronuclear myopathy (CNM): characterization and comparison with other CNM model zebrafish","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; Hospital for Sick Children; University of Toronto; University of New Brunswick","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Canadian Institutes of Health Research; Hospital for Sick Children","keywords":"Zebrafish; Biology; Phenotype; Desmin; Mutant; Myopathy; Genetics; Ventriculomegaly; Cell biology; Gene; Immunology; Immunohistochemistry; Fetus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003469915,0.0007823626,0.0004983238,0.001370231,0.0005671659,0.0003118445,0.0005680816,0.0007150106,0.002097219],"category_scores_gemma":[0.0002269317,0.0003228505,0.0005591281,0.0002489684,0.0006158166,0.0005021127,0.0005530688,0.0009410622,0.000439073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009696609,"about_ca_system_score_gemma":0.0005902943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006103547,"about_ca_topic_score_gemma":0.01018852,"domain_scores_codex":[0.999718,0.00001958005,0.00003594192,0.00009010181,0.00008435216,0.00005197856],"domain_scores_gemma":[0.9997287,0.0000220295,0.00009454783,0.00002382803,0.00004142067,0.00008944543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009046446,0.00004111658,0.000590522,0.00004124575,0.000009018214,0.0003616201,0.00004281658,0.00009558933,0.9973724,0.0002910852,0.0001019837,0.0009620744],"study_design_scores_gemma":[0.0001889619,0.002142935,0.0348992,0.00006888245,0.0001941016,0.006019964,0.0003192712,0.005332263,0.9397212,0.0004882739,0.01052676,0.00009811631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980882,0.0006443584,0.0132893,0.0003777544,0.00007173514,0.0003273769,0.002057215,0.000296375,0.002053884],"genre_scores_gemma":[0.9607396,0.00105611,0.02385682,0.0002296285,0.00002012141,0.0006561065,0.002004087,0.0001913718,0.01124613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006103547,"threshold_uncertainty_score":0.01213604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01701117720951767,"score_gpt":0.2147193685280935,"score_spread":0.1977081913185758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}