{"id":"W4200208542","doi":"10.1186/s13223-021-00620-8","title":"MiRNA-221-5p suppressed the Th17/Treg ratio in asthma via RORγt/Foxp3 by targeting SOCS1","year":2021,"lang":"en","type":"article","venue":"Allergy Asthma and Clinical Immunology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"RAR-related orphan receptor gamma; FOXP3; Suppressor of cytokine signaling 1; microRNA; Orphan receptor; Immunology; Cytokine; Receptor; Medicine; In vitro; Chemistry; Immune system; Internal medicine; Suppressor; Transcription factor; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003333296,0.000384689,0.0004870509,0.0002286135,0.0001945373,0.0004160866,0.0002199555,0.0003889815,0.001540012],"category_scores_gemma":[0.000214464,0.0001945579,0.0005256447,0.000105319,0.0004415608,0.0002218837,0.0002327636,0.0008690518,0.0003846674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002864201,"about_ca_system_score_gemma":0.0003855294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002090754,"about_ca_topic_score_gemma":0.0003379425,"domain_scores_codex":[0.9996784,0.0000481755,0.0000350639,0.00006879047,0.00008153271,0.00008807526],"domain_scores_gemma":[0.999882,0.00001482138,0.00004697502,0.00001138051,0.0000192907,0.00002547799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005690277,0.0000732468,0.0006578164,0.0003333025,0.00003231737,0.0001409775,0.0000456608,0.0002027627,0.9926468,0.0002956737,0.0002740328,0.004728321],"study_design_scores_gemma":[0.0002342709,0.002493509,0.006316839,0.00004829159,0.000225012,0.0008865485,0.00009578491,0.001892796,0.972886,0.0002277029,0.01467445,0.00001881107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9693996,0.01575277,0.00838868,0.000749796,0.0004476289,0.0001603636,0.0006693329,0.0005114618,0.003920323],"genre_scores_gemma":[0.9923397,0.002548981,0.002422214,0.0002567911,0.00005926977,0.0001227249,0.0003778965,0.00003184486,0.001840551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001540012,"threshold_uncertainty_score":0.005151808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01727796196081789,"score_gpt":0.3093789814411316,"score_spread":0.2921010194803138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}