{"id":"W4200208634","doi":"10.1093/ofid/ofab605","title":"Immunogenicity, Safety, and Tolerability of V114, a 15-Valent Pneumococcal Conjugate Vaccine, in Immunocompetent Adults Aged 18–49 Years With or Without Risk Factors for Pneumococcal Disease: A Randomized Phase 3 Trial (PNEU-DAY)","year":2021,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Pneumococcal conjugate vaccine; Tolerability; Pneumococcal polysaccharide vaccine; Immunogenicity; Pneumococcal vaccine; Vaccination; Adverse effect; Reactogenicity; Internal medicine; Streptococcus pneumoniae; Serotype; Randomized controlled trial; Immunology; Pneumococcal disease; Antigen; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002667589,0.001119379,0.001397758,0.0002317991,0.0003555212,0.0008068048,0.0006616006,0.001426289,0.003273526],"category_scores_gemma":[0.001791317,0.0004830042,0.00189221,0.0002510372,0.0007962078,0.0007894848,0.0003551003,0.002075702,0.0005269686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006851197,"about_ca_system_score_gemma":0.001238426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008170573,"about_ca_topic_score_gemma":0.001358268,"domain_scores_codex":[0.9992212,0.0004663384,0.00004935721,0.00009999188,0.00005929715,0.000103873],"domain_scores_gemma":[0.9989126,0.0002712577,0.0003447814,0.00007189286,0.0000927326,0.0003068246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9561673,0.01675039,0.00291581,0.0005859201,0.0009641239,0.00004771869,0.0001082469,0.0004041694,0.004178885,0.00005737263,0.0007058647,0.01711424],"study_design_scores_gemma":[0.7072077,0.2837195,0.006696703,0.00004138688,0.0004734256,0.00006337083,0.00003299612,0.0003739937,0.0007856353,0.0001033813,0.0004890873,0.00001274702],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957848,0.001340237,0.0002049099,0.0001581842,0.0001019918,0.001453017,0.0004039684,0.00002511469,0.0005277183],"genre_scores_gemma":[0.9938313,0.0009761579,0.000599062,0.000460577,0.0001415603,0.002599907,0.0006119165,0.00001050461,0.00076899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003273526,"threshold_uncertainty_score":0.01410776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01564548222050777,"score_gpt":0.3104574104464963,"score_spread":0.2948119282259885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}