{"id":"W4200208634","doi":"10.1093/ofid/ofab605","title":"Immunogenicity, Safety, and Tolerability of V114, a 15-Valent Pneumococcal Conjugate Vaccine, in Immunocompetent Adults Aged 18–49 Years With or Without Risk Factors for Pneumococcal Disease: A Randomized Phase 3 Trial (PNEU-DAY)","year":2021,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Pneumococcal conjugate vaccine; Tolerability; Pneumococcal polysaccharide vaccine; Immunogenicity; Pneumococcal vaccine; Vaccination; Adverse effect; Reactogenicity; Internal medicine; Streptococcus pneumoniae; Serotype; Randomized controlled trial; Immunology; Pneumococcal disease; Antigen; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007836938,0.0006031157,0.002454977,0.0002819445,0.00041624,0.0001760891,0.0002679676,0.0001723823,0.0003101436],"category_scores_gemma":[0.001943141,0.0004342402,0.0007550251,0.0005757615,0.0003742605,0.0003674342,0.0003907393,0.0004442525,0.000005276571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002288774,"about_ca_system_score_gemma":0.00120121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006847553,"about_ca_topic_score_gemma":0.001570078,"domain_scores_codex":[0.9954751,0.0009911333,0.001468422,0.000958823,0.0004204495,0.0006860667],"domain_scores_gemma":[0.9963374,0.001138317,0.0006496334,0.0008404987,0.0003779066,0.000656212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5479889,0.005382414,0.4412262,0.0003000786,0.0008258863,0.0001131738,0.0002598778,0.00007772067,0.002882845,0.00004194661,0.0000271532,0.0008737851],"study_design_scores_gemma":[0.5909244,0.003618777,0.400609,0.0005343482,0.001741673,0.0000630049,0.0003651372,0.000421785,0.0004593583,0.000183827,0.0005875262,0.0004911204],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857166,0.0005236262,0.0001488267,0.0002582497,0.0003829474,0.01145741,0.001144605,0.0001128834,0.000254805],"genre_scores_gemma":[0.9968073,0.0006234116,0.00002267012,0.0001545492,0.00007938817,0.001740947,0.0003193127,0.00008481623,0.0001676422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04293551,"threshold_uncertainty_score":0.9998109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01564548222050777,"score_gpt":0.3104574104464963,"score_spread":0.2948119282259885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}