{"id":"W4200216254","doi":"10.1128/spectrum.00804-21","title":"The <i>de novo</i> Purine Biosynthesis Pathway Is the Only Commonly Regulated Cellular Pathway during Biofilm Formation in TSB-Based Medium in Staphylococcus aureus and Enterococcus faecalis","year":2021,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de recherche du Québec; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Biofilm; Enterococcus faecalis; Biosynthesis; Purine; Metabolic pathway; Staphylococcus aureus; Bacteria; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009274152,0.0002992198,0.0002518302,0.0001936824,0.0001961752,0.0003989584,0.0001119078,0.0002537864,0.0008286558],"category_scores_gemma":[0.0001966589,0.000110524,0.0002530304,0.0001773196,0.0001992675,0.0003878871,0.0002490864,0.0004641814,0.0002784767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002526088,"about_ca_system_score_gemma":0.0002929217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001291073,"about_ca_topic_score_gemma":0.00143751,"domain_scores_codex":[0.9998527,0.0000237966,0.00001267395,0.00004203885,0.00003442816,0.00003444005],"domain_scores_gemma":[0.99981,0.0000342349,0.00004959028,0.00001622485,0.0000387835,0.00005124458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007381356,0.00000693728,0.0002494688,0.00003077426,0.000001491911,0.00003151746,0.00001461109,0.00001808344,0.9987519,0.00003845488,0.00001981959,0.0007631573],"study_design_scores_gemma":[0.000003736439,0.0002177898,0.01933042,0.00001356985,0.00001122795,0.0002964041,0.0001502971,0.0005666513,0.9778472,0.0001078897,0.001444298,0.00001056353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917441,0.002055743,0.002688062,0.0002323538,0.00003469701,0.0000224611,0.0008303358,0.00007574557,0.002316595],"genre_scores_gemma":[0.9939563,0.0005606819,0.002556458,0.00007105414,0.000005151997,0.00002617111,0.0009656238,0.00001775852,0.001840913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001291073,"threshold_uncertainty_score":0.002772093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004722283706474469,"score_gpt":0.1871973946902545,"score_spread":0.18247511098378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}