{"id":"W4200216254","doi":"10.1128/spectrum.00804-21","title":"The <i>de novo</i> Purine Biosynthesis Pathway Is the Only Commonly Regulated Cellular Pathway during Biofilm Formation in TSB-Based Medium in Staphylococcus aureus and Enterococcus faecalis","year":2021,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de recherche du Québec; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Biofilm; Enterococcus faecalis; Biosynthesis; Purine; Metabolic pathway; Staphylococcus aureus; Bacteria; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004119375,0.0002966339,0.0002898122,0.00008511495,0.0002644279,0.00008265431,0.0002706063,0.0003606779,0.00002215165],"category_scores_gemma":[0.00006350897,0.0002089792,0.0001109416,0.0002446207,0.0002761249,0.00001030884,0.0002203924,0.0002822761,0.000004932101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007138206,"about_ca_system_score_gemma":0.0001409676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001461524,"about_ca_topic_score_gemma":0.006642486,"domain_scores_codex":[0.9979168,0.000388291,0.0004821359,0.0004972297,0.00005593922,0.0006595665],"domain_scores_gemma":[0.9991013,0.00007025326,0.0001622159,0.0005551929,0.00004561532,0.00006541023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002007968,0.00007210852,0.00313788,0.00002399664,0.00003271141,0.00007763385,0.0001562325,0.000009932996,0.9956147,0.0000323677,0.00007446195,0.0005671681],"study_design_scores_gemma":[0.001093503,0.0001051114,0.007413569,0.00004345598,0.00001050231,0.0001385808,0.0002102922,0.00006483612,0.9726552,0.00002369618,0.01799093,0.0002503117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903848,0.001662426,0.00002660088,0.007170431,0.0002055877,0.0003108107,0.0001629444,0.00001798898,0.00005837335],"genre_scores_gemma":[0.9980898,0.0003067213,0.00009775392,0.0009211827,0.0001236484,0.00001358785,0.0003313966,0.00002844857,0.00008739192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0229595,"threshold_uncertainty_score":0.8521926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004722283706474469,"score_gpt":0.1871973946902545,"score_spread":0.18247511098378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}