{"id":"W4200216655","doi":"10.1016/j.annonc.2021.10.168","title":"149P KEYNOTE-629: Efficacy of pembrolizumab (Pembro) per immune-related RECIST (irRECIST) in locally advanced (LA) and recurrent or metastatic (R/M) cutaneous squamous cell carcinoma (cSCC)","year":2021,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Medicine; Pembrolizumab; Oncology; Basal cell; Response Evaluation Criteria in Solid Tumors; Immunotherapy; Internal medicine; Dermatology; Cancer research; Cancer; Chemotherapy; Phases of clinical research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006234017,0.0005770185,0.0009177742,0.0003320691,0.0002235715,0.0006910889,0.0006206739,0.001096711,0.01499075],"category_scores_gemma":[0.0007212978,0.0002234888,0.0009159746,0.0002510199,0.000218333,0.000550215,0.0002862476,0.002478806,0.002841557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007476581,"about_ca_system_score_gemma":0.0006243539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009455776,"about_ca_topic_score_gemma":0.002771999,"domain_scores_codex":[0.9998461,0.00004711215,0.0000134357,0.00002874524,0.00002628821,0.00003822079],"domain_scores_gemma":[0.9997563,0.00007179113,0.00003964029,0.0000217605,0.00002775778,0.0000826921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3557763,0.01062437,0.003004057,0.002037843,0.001164857,0.0004803334,0.00008826132,0.001614072,0.03253346,0.00103559,0.08296593,0.508675],"study_design_scores_gemma":[0.4909852,0.2874059,0.05409113,0.0008923911,0.003944029,0.001956988,0.0001124947,0.004554262,0.02996826,0.001717136,0.1242323,0.0001399464],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8452502,0.03904426,0.001686084,0.01311348,0.00610542,0.003338423,0.01918182,0.001120398,0.07115979],"genre_scores_gemma":[0.9332712,0.01154675,0.002512267,0.005092193,0.002018101,0.001055228,0.01148773,0.0001368342,0.03287983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01499075,"threshold_uncertainty_score":0.05014902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04072669482743754,"score_gpt":0.3481350470435178,"score_spread":0.3074083522160803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}