{"id":"W4200221118","doi":"10.1038/s41598-021-02795-x","title":"Quantitative proteomic screen identifies annexin A2 as a host target for Salmonella pathogenicity island-2 effectors SopD2 and PipB2","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Salmonella and Campylobacter epidemiology","field":"Agricultural and Biological Sciences","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Genome British Columbia; Genome Canada","keywords":"Effector; Biology; Salmonella enterica; Intracellular; Salmonella; Vacuole; Secretion; Pathogenicity island; Intracellular parasite; Annexin A2; Cell biology; Type three secretion system; Microbiology; Stable isotope labeling by amino acids in cell culture; Mutant; Cytoplasm; Annexin; Genetics; Bacteria; Biochemistry; Gene; Cell; Proteomics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001100416,0.0002851885,0.0002584779,0.0003433514,0.0001799688,0.0002832513,0.0002055869,0.0003235959,0.001051817],"category_scores_gemma":[0.000111818,0.0001418788,0.0002613926,0.0003052177,0.0001077745,0.0001563666,0.0001743412,0.0003139587,0.0003716268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002191696,"about_ca_system_score_gemma":0.0001223188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005933961,"about_ca_topic_score_gemma":0.0008415346,"domain_scores_codex":[0.9998643,0.00001712126,0.0000090119,0.00003537125,0.00005173256,0.00002236407],"domain_scores_gemma":[0.9999229,0.00001654077,0.000015486,0.000005761312,0.00001850677,0.00002079328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000389991,0.00001129495,0.0002376162,0.00001104412,0.000003915168,0.00002741483,0.000003397614,0.00001402697,0.9994401,0.000009122121,0.00001062292,0.0001923788],"study_design_scores_gemma":[0.000008416877,0.0001892993,0.01156813,0.000003957345,0.00002019506,0.0003972115,0.00005173556,0.001660106,0.9844106,0.000028824,0.001654577,0.000006868253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939454,0.0008112774,0.003272666,0.00007753354,0.00001870215,0.00003136417,0.0008073442,0.00005828982,0.0009773967],"genre_scores_gemma":[0.9845486,0.0007606248,0.007596723,0.000116295,0.00001037629,0.00004916152,0.00313306,0.00002703795,0.003758128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001051817,"threshold_uncertainty_score":0.003518641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02414390260829322,"score_gpt":0.2664388487732776,"score_spread":0.2422949461649843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}