{"id":"W4200223554","doi":"10.1038/s41598-021-03242-7","title":"Pharmacokinetics and central accumulation of delta-9-tetrahydrocannabinol (THC) and its bioactive metabolites are influenced by route of administration and sex in rats","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; University of Calgary","funders":"Canadian Institutes of Health Research; Hotchkiss Brain Institute, University of Calgary; Branch Out Neurological Foundation; Hotchkiss Brain Institute; Mathison Centre for Mental Health Research and Education; Cumming School of Medicine, University of Calgary; University of Calgary","keywords":"Pharmacokinetics; Delta-9-tetrahydrocannabinol; Pharmacology; Tetrahydrocannabinol; Δ9-tetrahydrocannabinol; Medicine; Administration (probate law); Route of administration; Metabolite; Chemistry; Biology; Internal medicine; Cannabinoid; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001175199,0.0003381482,0.0002798663,0.0004712624,0.0001858889,0.0003033506,0.0001576983,0.0002327164,0.001554857],"category_scores_gemma":[0.0002502958,0.000255792,0.000290136,0.0001687972,0.0004306143,0.0003784134,0.0001545479,0.0007115208,0.0005448472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004396115,"about_ca_system_score_gemma":0.0004385865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00287627,"about_ca_topic_score_gemma":0.005533546,"domain_scores_codex":[0.9998181,0.00001777567,0.000009266132,0.00005283343,0.00005772067,0.0000442751],"domain_scores_gemma":[0.9997126,0.00003853603,0.00010313,0.00004198465,0.00003919244,0.00006446865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004373223,0.000528391,0.009596308,0.00006342294,0.00004637985,0.0001549886,0.0001785991,0.00015954,0.9651147,0.0001516576,0.0002748847,0.01935801],"study_design_scores_gemma":[0.00008486802,0.007790416,0.1463572,0.00001784827,0.000144443,0.0006293749,0.0003443762,0.002131945,0.8382668,0.0003037301,0.003846009,0.00008315433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962311,0.0009312112,0.001352106,0.00008012058,0.00002627317,0.00002253799,0.0005602345,0.00006387148,0.0007325218],"genre_scores_gemma":[0.9862188,0.002061013,0.003072999,0.0001033923,0.00002059756,0.00008056976,0.0007737895,0.00006503269,0.007603825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00287627,"threshold_uncertainty_score":0.005719066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03091673963382574,"score_gpt":0.3433784579389579,"score_spread":0.3124617183051322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}