{"id":"W4200227978","doi":"10.1089/nat.2021.0085","title":"Challenges and Opportunities for Nucleic Acid Therapeutics","year":2021,"lang":"en","type":"article","venue":"Nucleic Acid Therapeutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences","keywords":"Nucleic acid; Computational biology; Oligonucleotide; RNA; Risk analysis (engineering); Biology; Computer science; Medicine; DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01332293,0.001471087,0.002443668,0.001273136,0.002856993,0.007012689,0.002148234,0.008737757,0.01282749],"category_scores_gemma":[0.006428328,0.0006243896,0.001298829,0.0007812365,0.01046478,0.01607314,0.006517931,0.01380137,0.00523031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002871131,"about_ca_system_score_gemma":0.007480843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000755999,"about_ca_topic_score_gemma":0.001186595,"domain_scores_codex":[0.9955574,0.001613502,0.000266073,0.0005505505,0.001474487,0.0005380602],"domain_scores_gemma":[0.9932254,0.003898082,0.0003388217,0.0003589506,0.001096537,0.001082116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003787541,0.0004993883,0.0004534662,0.003479559,0.0001019802,0.0007369217,0.000935246,0.002118851,0.01208394,0.6375511,0.129767,0.2118938],"study_design_scores_gemma":[0.0000734363,0.0004021689,0.0002034389,0.0009690131,0.00003340037,0.0007768783,0.001229757,0.001034102,0.002010351,0.3245913,0.6686006,0.00007564511],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003062704,0.60073,0.02964815,0.3269561,0.008095304,0.00009978007,0.0001612718,0.0002907372,0.030956],"genre_scores_gemma":[0.06675931,0.7273877,0.06134556,0.09831735,0.01492916,0.0008463596,0.0003770645,0.0002614636,0.02977597],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01332293,"threshold_uncertainty_score":0.07045925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1087903394401578,"score_gpt":0.2952986628247805,"score_spread":0.1865083233846227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}