{"id":"W4200244636","doi":"10.20944/preprints202112.0315.v1","title":"Niosomes: A Novel Targeted Drug Delivery System","year":2021,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"","keywords":"Niosome; ADME; Drug delivery; Nanotechnology; In silico; Bioavailability; Nanomedicine; Drug; Targeted drug delivery; Liposome; Biochemical engineering; Chemistry; Materials science; Pharmacology; Nanoparticle; Medicine; Vesicle; Engineering; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001511075,0.0004063736,0.0004507365,0.0003952229,0.0002246776,0.0005525431,0.0004530047,0.0005118033,0.001132993],"category_scores_gemma":[0.0001306786,0.0001978047,0.0002736476,0.0002283503,0.0001802783,0.0006384247,0.0004002244,0.0004305788,0.00126128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005310923,"about_ca_system_score_gemma":0.0004101096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000878024,"about_ca_topic_score_gemma":0.0009469719,"domain_scores_codex":[0.9998139,0.00002449083,0.00002167389,0.00005623389,0.00005842532,0.00002535844],"domain_scores_gemma":[0.9999611,0.000004367937,0.00001029706,0.000003085515,0.00001300592,0.000008153101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002259796,0.00007523171,0.000215287,0.001074504,0.00003923017,0.0002623977,0.00005028594,0.0005608907,0.9514101,0.002616508,0.002446631,0.04102304],"study_design_scores_gemma":[0.0000712847,0.0005199359,0.0008572392,0.00007131911,0.00009724258,0.001196948,0.00002612552,0.003786915,0.8336079,0.0003479861,0.1593717,0.0000455173],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5048409,0.2255187,0.1843072,0.003659043,0.001413331,0.001789081,0.00368646,0.005671468,0.06911379],"genre_scores_gemma":[0.7857208,0.06567314,0.1003816,0.001254731,0.000209419,0.0009003702,0.003080955,0.0003430776,0.04243591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001132993,"threshold_uncertainty_score":0.003853381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.234696337541028,"score_gpt":0.4426030321452737,"score_spread":0.2079066946042457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}