{"id":"W4200244636","doi":"10.20944/preprints202112.0315.v1","title":"Niosomes: A Novel Targeted Drug Delivery System","year":2021,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"","keywords":"Niosome; ADME; Drug delivery; Nanotechnology; In silico; Bioavailability; Nanomedicine; Drug; Targeted drug delivery; Liposome; Biochemical engineering; Chemistry; Materials science; Pharmacology; Nanoparticle; Medicine; Vesicle; Engineering; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.001646878,0.001091785,0.001268803,0.0003326387,0.0004505033,0.00005064972,0.001826876,0.001512753,0.006187289],"category_scores_gemma":[0.0001976927,0.001259304,0.000681838,0.0003586801,0.0004070745,0.0002884023,0.003736579,0.005453425,0.002872325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009340058,"about_ca_system_score_gemma":0.0007549216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002694366,"about_ca_topic_score_gemma":0.00005257363,"domain_scores_codex":[0.9931742,0.001066442,0.001437283,0.002265744,0.0006941675,0.001362165],"domain_scores_gemma":[0.9956721,0.0004799688,0.0007196754,0.001896328,0.0005892004,0.0006427239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001662077,0.004692893,0.4455884,0.009106647,0.00830188,0.002212568,0.01270771,0.08212088,0.4249011,0.001238627,0.002104005,0.005363227],"study_design_scores_gemma":[0.008753831,0.0000631301,0.0840271,0.00251059,0.003210325,0.0003056502,0.006993756,0.01996149,0.7055905,0.0003652837,0.162857,0.005361288],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9688631,0.00332577,0.001726132,0.0004443608,0.009651064,0.001762468,0.0005504456,0.0009461637,0.01273052],"genre_scores_gemma":[0.9904652,0.001523636,0.0009955371,0.001535586,0.0007438054,0.0006706528,0.0006001942,0.0001756505,0.003289722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3615613,"threshold_uncertainty_score":0.9997835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.234696337541028,"score_gpt":0.4426030321452737,"score_spread":0.2079066946042457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}