{"id":"W4200247047","doi":"10.3390/biomed1020013","title":"Mast Cell Tryptase and Implications for SARS-CoV-2 Pathogenesis","year":2021,"lang":"en","type":"article","venue":"BioMed","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Tryptase; Proteases; Pathogenesis; Immunology; Degranulation; Coronavirus; Mast cell; Angiotensin-converting enzyme 2; Biology; Chymase; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Innate immune system; Virology; Receptor; Disease; Medicine; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty); Immune system; Enzyme; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000428616,0.00007435011,0.0001168126,0.00003910897,0.0001227433,0.00001006267,0.00005132489,0.00009740343,0.0001074368],"category_scores_gemma":[0.00001302801,0.00007011056,0.00004399303,0.00008547011,0.00007008043,0.00001502209,0.00003573642,0.00003000478,0.00006799286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007974614,"about_ca_system_score_gemma":0.00003283576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001392962,"about_ca_topic_score_gemma":0.00002816383,"domain_scores_codex":[0.9995015,0.00002454731,0.000114206,0.00019647,0.000006374336,0.0001568779],"domain_scores_gemma":[0.9996786,0.00004470271,0.00003550941,0.0001782713,0.00005158686,0.00001134662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000017496,0.00008207515,0.0002137621,0.00003001353,0.00001828546,0.000001327948,0.00004472161,9.728589e-9,0.9775047,0.0007837847,0.01336086,0.007942991],"study_design_scores_gemma":[0.0005726295,0.00002617,0.004727385,0.000001948604,0.00002116728,0.00001662645,0.00002995985,5.423941e-7,0.5101851,0.00009353091,0.4842612,0.00006367895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750148,0.01424664,0.002034079,0.002945198,0.000616424,0.0003700111,0.001609663,0.00006969902,0.003093509],"genre_scores_gemma":[0.9865406,0.0002425897,0.001746357,0.0004416378,0.00004199244,0.00009064109,0.001050464,0.00001755244,0.009828186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4709004,"threshold_uncertainty_score":0.2859026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02418112007639946,"score_gpt":0.255977506010383,"score_spread":0.2317963859339836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}