{"id":"W4200247221","doi":"10.1101/2021.12.17.473248","title":"SARS-CoV-2 Omicron spike mediated immune escape and tropism shift","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Strategic International Collaborative Research Program; Core Research for Evolutional Science and Technology; Research Institute for Microbial Diseases, Osaka University; Japan Society for the Promotion of Science; NIHR BioResource; National Institute for Health and Care Research; Institute of Genetics; Fast Grants; Engineering and Physical Sciences Research Council; UK Research and Innovation; Rosetrees Trust; Tokyo Biochemical Research Foundation; Wellcome Trust; Bill and Melinda Gates Foundation; Japan Agency for Medical Research and Development; European Association for the Study of the Liver; Burroughs Wellcome Fund; NHS Blood and Transplant; National Institute of Allergy and Infectious Diseases; Medical Research Council; Howard Hughes Medical Institute","keywords":"Biology; Viral entry; Virology; Tropism; Virus; Viral replication; Cell biology; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007280836,0.0002643185,0.0001825077,0.00008316626,0.00008597162,0.0002387335,0.000105045,0.000226672,0.001956516],"category_scores_gemma":[0.00009081046,0.00009393525,0.0002775347,0.00006138755,0.0001146409,0.0001206211,0.0001812364,0.0004875442,0.0004824838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002549221,"about_ca_system_score_gemma":0.00009983431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004119533,"about_ca_topic_score_gemma":0.0004271985,"domain_scores_codex":[0.9998809,0.00001704322,0.000007090598,0.00001900587,0.00003634687,0.00003964235],"domain_scores_gemma":[0.9999425,0.00001214394,0.00001365294,0.000009269618,0.00001121509,0.00001114686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000436818,0.0000115661,0.0002137035,0.00001005771,0.000001563686,0.00002995102,0.00000565488,0.00003610785,0.9990791,0.00002927658,0.00002229289,0.0005170024],"study_design_scores_gemma":[0.0000174285,0.001007771,0.01853343,0.000006786757,0.000009825787,0.001474681,0.00009467557,0.002288865,0.9743418,0.0001114064,0.00210552,0.000007883294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981111,0.000208921,0.0006560861,0.00003793658,0.00000783863,0.00001232598,0.0001790253,0.00001841882,0.0007682742],"genre_scores_gemma":[0.9979969,0.00007799485,0.0004267003,0.00004286035,0.000003468529,0.00000900365,0.0003440581,0.000005970308,0.001092967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001956516,"threshold_uncertainty_score":0.006545246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0244949414002356,"score_gpt":0.2786243298119739,"score_spread":0.2541293884117383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}