{"id":"W4200247221","doi":"10.1101/2021.12.17.473248","title":"SARS-CoV-2 Omicron spike mediated immune escape and tropism shift","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Strategic International Collaborative Research Program; Core Research for Evolutional Science and Technology; Research Institute for Microbial Diseases, Osaka University; Japan Society for the Promotion of Science; NIHR BioResource; National Institute for Health and Care Research; Institute of Genetics; Fast Grants; Engineering and Physical Sciences Research Council; UK Research and Innovation; Rosetrees Trust; Tokyo Biochemical Research Foundation; Wellcome Trust; Bill and Melinda Gates Foundation; Japan Agency for Medical Research and Development; European Association for the Study of the Liver; Burroughs Wellcome Fund; NHS Blood and Transplant; National Institute of Allergy and Infectious Diseases; Medical Research Council; Howard Hughes Medical Institute","keywords":"Biology; Viral entry; Virology; Tropism; Virus; Viral replication; Cell biology; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009440075,0.0009836656,0.001580649,0.000668451,0.0002101468,0.0004670181,0.000664416,0.001238757,0.00003160668],"category_scores_gemma":[0.0007658654,0.00101331,0.0003853083,0.0008901653,0.0003867796,0.0002028395,0.001316263,0.002223807,0.0001825233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005298913,"about_ca_system_score_gemma":0.002492781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005137397,"about_ca_topic_score_gemma":0.00002430872,"domain_scores_codex":[0.9947426,0.0002610573,0.001004827,0.001862777,0.0009568611,0.001171902],"domain_scores_gemma":[0.9961864,0.0001771465,0.0004074315,0.002290738,0.0007288551,0.0002094289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002245483,0.0003114564,0.01860289,0.001224095,0.0004337964,0.0009156682,0.00004258614,1.658985e-7,0.9779277,0.00008789562,0.0002201674,0.00000901684],"study_design_scores_gemma":[0.002221594,0.000142444,0.1286632,0.00092476,0.0002729818,3.034409e-7,0.000009701525,0.0001602163,0.8411766,0.000001811737,0.02558261,0.0008437604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846095,0.01122588,0.0002265567,0.0008871177,0.001030517,0.00131298,0.0001174413,0.0005361606,0.00005385296],"genre_scores_gemma":[0.9866215,0.0003690484,0.001383699,0.01040686,0.00068159,0.0002455737,0.000001816747,0.000287157,0.000002746945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1367511,"threshold_uncertainty_score":0.9992318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0244949414002356,"score_gpt":0.2786243298119739,"score_spread":0.2541293884117383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}