{"id":"W4200249038","doi":"10.1161/circresaha.121.319044","title":"Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging","year":2021,"lang":"en","type":"article","venue":"Circulation Research","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute","keywords":"Endothelial protein C receptor; Protein C; Medicine; Internal medicine; Endocrinology; Wild type; Thrombin; Immunology; Biology; Mutant; Biochemistry; Platelet; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002846897,0.0005139237,0.0004710174,0.0003247419,0.0001512317,0.0002248582,0.0002246381,0.0003485855,0.001529928],"category_scores_gemma":[0.0001796775,0.0001213912,0.0003273495,0.0001170726,0.0003286256,0.0002393261,0.0002472796,0.0007271837,0.0002257153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001728255,"about_ca_system_score_gemma":0.0002356493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002024438,"about_ca_topic_score_gemma":0.0002808588,"domain_scores_codex":[0.9999059,0.00001112642,0.000008869625,0.00002257373,0.00001775173,0.00003373429],"domain_scores_gemma":[0.9997874,0.000009987089,0.00006690907,0.00001985126,0.00002639159,0.00008953184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002105135,0.0002896825,0.001337171,0.0001565911,0.00002919685,0.0002480211,0.00003793999,0.00006417292,0.9886661,0.0001673298,0.0002439631,0.006654708],"study_design_scores_gemma":[0.0003891388,0.01388837,0.102204,0.00008084893,0.0003391581,0.002089401,0.0001530715,0.001584975,0.8693352,0.000506727,0.00939108,0.00003781428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948939,0.002625073,0.0009211114,0.0001445357,0.00009161641,0.00003300254,0.0001741739,0.00009020739,0.00102651],"genre_scores_gemma":[0.9942188,0.001633159,0.001061625,0.0001551108,0.00008514048,0.00006371014,0.0003317746,0.00002102501,0.002429682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001529928,"threshold_uncertainty_score":0.005118132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08353560594813098,"score_gpt":0.3799607246178711,"score_spread":0.2964251186697401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}