{"id":"W4200249038","doi":"10.1161/circresaha.121.319044","title":"Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging","year":2021,"lang":"en","type":"article","venue":"Circulation Research","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute","keywords":"Endothelial protein C receptor; Protein C; Medicine; Internal medicine; Endocrinology; Wild type; Thrombin; Immunology; Biology; Mutant; Biochemistry; Platelet; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006264436,0.00008976172,0.0002173955,0.0003069041,0.0000898499,0.00004296517,0.00006320847,0.00009716763,0.0002159064],"category_scores_gemma":[0.000500509,0.00009688878,0.00005041542,0.001552803,0.00002306411,0.00009524971,0.00006464194,0.0003910419,0.0001249812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001599904,"about_ca_system_score_gemma":0.0002591466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007341633,"about_ca_topic_score_gemma":0.00002239733,"domain_scores_codex":[0.9982229,0.0002196535,0.0002315903,0.0003621382,0.0006327522,0.0003310066],"domain_scores_gemma":[0.9988417,0.00007312783,0.00002536517,0.000363569,0.0005286277,0.0001675933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003393514,0.0001200907,0.01363695,0.000054842,0.00001914883,0.00002422013,0.0007560364,0.0003658798,0.9784999,0.0007649757,0.0001476896,0.005576354],"study_design_scores_gemma":[0.001156651,0.00003985489,0.330883,0.0003904705,0.000006460388,0.000004398032,0.0004624127,0.002273989,0.6620394,0.0002748386,0.002338803,0.0001297891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911584,0.0001265796,0.0001639434,0.00326478,0.00006441026,0.000722043,0.000003597041,0.0000504182,0.004445825],"genre_scores_gemma":[0.9982881,0.000007231919,0.0004864788,0.0001437981,0.00009832964,0.00009772843,0.00005216542,0.00002105879,0.0008051299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.317246,"threshold_uncertainty_score":0.395101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08353560594813098,"score_gpt":0.3799607246178711,"score_spread":0.2964251186697401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}