{"id":"W4200251363","doi":"10.1128/mbio.03137-21","title":"OXA-23 β-Lactamase Overexpression in Acinetobacter baumannii Drives Physiological Changes Resulting in New Genetic Vulnerabilities","year":2021,"lang":"en","type":"article","venue":"mBio","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; University of Guelph","funders":"National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Government of Canada; National Institute of Allergy and Infectious Diseases; U.S. Department of Veterans Affairs","keywords":"Acinetobacter baumannii; Microbiology; Biology; Computational biology; Bacteria; Genetics; Pseudomonas aeruginosa","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001120548,0.0001947749,0.0002356936,0.00004684261,0.00004018434,0.00003819772,0.0001701106,0.0002302617,0.0001028718],"category_scores_gemma":[0.0003110397,0.0001747382,0.00005715366,0.0001204937,0.00008391232,0.000006724632,0.000212842,0.0001615064,0.00001164689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003291668,"about_ca_system_score_gemma":0.0001038878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006196518,"about_ca_topic_score_gemma":0.000568348,"domain_scores_codex":[0.9985268,0.0001777208,0.0002852029,0.0005488492,0.0001056901,0.000355724],"domain_scores_gemma":[0.9993669,0.00003149663,0.0000774205,0.000411758,0.0000383543,0.0000740526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000111875,0.00007527645,0.0590691,0.00003356799,0.00000737962,0.00003615564,0.0001584239,0.00002838083,0.9382685,0.00001760873,0.001422422,0.0007712436],"study_design_scores_gemma":[0.0008276327,0.0001160491,0.5770608,0.0002359759,0.000003154222,0.000007793683,0.0003766736,0.00003744086,0.4171349,0.0001644258,0.003790428,0.0002447516],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982261,0.0006913596,0.00003848505,0.000330113,0.0001001555,0.0001318073,0.0000129237,0.00001220037,0.0004568743],"genre_scores_gemma":[0.9946505,0.0002770142,0.001843458,0.000248616,0.0003244367,0.000006596262,0.0001581331,0.00002029215,0.002470913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5211337,"threshold_uncertainty_score":0.7125617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01874589486143991,"score_gpt":0.2650381098577938,"score_spread":0.2462922149963539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}