{"id":"W4200251363","doi":"10.1128/mbio.03137-21","title":"OXA-23 β-Lactamase Overexpression in Acinetobacter baumannii Drives Physiological Changes Resulting in New Genetic Vulnerabilities","year":2021,"lang":"en","type":"article","venue":"mBio","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; University of Guelph","funders":"National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Government of Canada; National Institute of Allergy and Infectious Diseases; U.S. Department of Veterans Affairs","keywords":"Acinetobacter baumannii; Microbiology; Biology; Computational biology; Bacteria; Genetics; Pseudomonas aeruginosa","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000105182,0.0002866149,0.0002260148,0.000111785,0.0001506888,0.0004745909,0.0001494457,0.0002711846,0.0007849846],"category_scores_gemma":[0.0001509851,0.0001207392,0.0001802429,0.0001272312,0.0002181435,0.0001815188,0.0003017561,0.0005477943,0.0003358987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000338089,"about_ca_system_score_gemma":0.0002366161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009047838,"about_ca_topic_score_gemma":0.000939781,"domain_scores_codex":[0.9998459,0.00002621542,0.00001798508,0.00002600231,0.00004564653,0.00003822038],"domain_scores_gemma":[0.9998847,0.00002070684,0.00003508107,0.00001602912,0.00001101714,0.00003249476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002473254,0.00001289743,0.0001047039,0.000008322157,0.000001117279,0.00004564937,0.00000858106,0.00003164532,0.9994542,0.00004358919,0.00001508904,0.0002495581],"study_design_scores_gemma":[0.00000701178,0.0001874893,0.006670097,0.000006521421,0.000007170513,0.0005362391,0.0001491083,0.001318844,0.9891739,0.0001010273,0.001833335,0.000009337228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971545,0.0003805798,0.001246781,0.000150709,0.0000262914,0.00001257811,0.0002181754,0.00006797731,0.0007424387],"genre_scores_gemma":[0.9964188,0.0003815585,0.001320059,0.00005304825,0.000004896884,0.00001701327,0.0002935721,0.00002642564,0.001484521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009047838,"threshold_uncertainty_score":0.002626061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01874589486143991,"score_gpt":0.2650381098577938,"score_spread":0.2462922149963539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}