{"id":"W4200252581","doi":"10.3389/fonc.2021.781800","title":"Pseudomonas Exotoxin-Based Immunotoxins: Over Three Decades of Efforts on Targeting Cancer Cells With the Toxin","year":2021,"lang":"en","type":"review","venue":"Frontiers in Oncology","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Immunotoxin; Pseudomonas exotoxin; Diphtheria toxin; Cancer cell; Exotoxin; Antibody; Cancer research; Cancer; Medicine; Cytotoxicity; Toxin; Biology; Immunology; Monoclonal antibody; Microbiology; Biochemistry; In vitro; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001036533,0.0009975451,0.004019405,0.0005859981,0.0002727266,0.00002920489,0.00127764,0.001940712,0.0009124776],"category_scores_gemma":[0.00009692001,0.0006420128,0.0007935482,0.0007911149,0.0007785379,0.00007575718,0.0002499457,0.002223036,0.00004835987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008589725,"about_ca_system_score_gemma":0.001932911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002816039,"about_ca_topic_score_gemma":0.0004191439,"domain_scores_codex":[0.9949749,0.001325447,0.001403612,0.00105288,0.0001680463,0.001075157],"domain_scores_gemma":[0.9963906,0.0009424298,0.00139142,0.001111316,0.0001179096,0.00004628243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005403785,0.001057938,0.0001422638,0.002838495,0.002439359,0.0002433394,0.0003657675,0.000219298,0.009254247,0.0007314489,0.0578,0.9243675],"study_design_scores_gemma":[0.002052512,0.0009660838,0.00001705714,0.006109402,0.0007044419,0.00003373692,0.0002341791,0.000007711771,0.01081939,0.00003900906,0.9783047,0.0007118027],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009491287,0.9897186,0.001137262,0.0001174875,0.005275354,0.00207943,0.000237378,0.00005378334,0.0004316492],"genre_scores_gemma":[0.00043278,0.9934053,0.002961227,0.0004474321,0.0001277145,0.001215745,0.0003169594,0.0001742711,0.0009185214],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9236557,"threshold_uncertainty_score":0.9996031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01990583187260016,"score_gpt":0.2954168497310917,"score_spread":0.2755110178584916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}