{"id":"W4200254386","doi":"10.3390/cells10123450","title":"Reprogramming Human Adult Fibroblasts into GABAergic Interneurons","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Medical Research Council; Hjärnfonden; Kungliga Fysiografiska Sällskapet i Lund; Lunds Universitet; National Institute for Health and Care Research; Department of Health and Social Care; Wellcome Trust; Åhlén-stiftelsen; Vetenskapsrådet; Jeanssons Stiftelser","keywords":"Reprogramming; GABAergic; Neuroscience; Biology; Gene silencing; Transcription factor; Cell type; Cell biology; Cell; Inhibitory postsynaptic potential; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001007155,0.0001379744,0.0001187082,0.00003406006,0.00009675757,0.00005906905,0.0002483434,0.0001142568,0.0001108869],"category_scores_gemma":[0.00006776233,0.0001451679,0.0001184289,0.0001143975,0.00007798858,0.000003042825,0.0004287004,0.0001388678,0.0001890227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001737367,"about_ca_system_score_gemma":0.00006069557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002639834,"about_ca_topic_score_gemma":0.00009207501,"domain_scores_codex":[0.9986788,0.00008861476,0.0001866858,0.0005388177,0.0001737835,0.0003332875],"domain_scores_gemma":[0.9990509,0.000010425,0.0000441366,0.0005965423,0.0001667275,0.0001312654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001173768,0.00006827395,0.0002651438,0.00005003011,0.00002615348,0.00008990282,0.0000467946,0.00001947839,0.9906423,0.0000379287,0.007106113,0.001636159],"study_design_scores_gemma":[0.0002582179,0.0001257784,0.0001149343,0.00002632525,0.000005915261,0.0000210371,0.0000560457,0.00003282908,0.9103603,0.00004809732,0.08880454,0.0001459217],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912006,0.0004789948,0.0005329629,0.0001911973,0.0002142043,0.0001261593,0.000004964447,0.00002616026,0.007224728],"genre_scores_gemma":[0.9792167,0.0001220798,0.001019947,0.0002231576,0.0002391133,0.00001595406,0.0001329551,0.00003334352,0.01899674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08169843,"threshold_uncertainty_score":0.5919777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0103463331465318,"score_gpt":0.2771355925451147,"score_spread":0.2667892593985829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}