{"id":"W4200256736","doi":"10.1101/2021.12.09.472005","title":"Epistatic genetic interactions govern morphogenesis during sexual reproduction and infection in a global human fungal pathogen","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Canadian Institute for Advanced Research","keywords":"Biology; Genetics; Epistasis; Phenotype; Quantitative trait locus; Sexual reproduction; Gene; Population; Locus (genetics); Mating type; Evolutionary biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002005227,0.0002223097,0.0001641291,0.0004416862,0.0001632929,0.0001996935,0.00015218,0.000153161,0.001056844],"category_scores_gemma":[0.0002544008,0.0001304847,0.0001795725,0.0002321105,0.00019046,0.0000674149,0.0003268889,0.0002808009,0.0001044337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000225132,"about_ca_system_score_gemma":0.0001737389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001141489,"about_ca_topic_score_gemma":0.001811989,"domain_scores_codex":[0.9997715,0.00005872025,0.0000143255,0.00005813595,0.00005621671,0.00004108653],"domain_scores_gemma":[0.9998336,0.00005228917,0.00005092517,0.00001549625,0.00001620167,0.00003147297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008532615,0.00002235132,0.006249463,0.00000849898,0.00001062594,0.0001045135,0.00002334741,0.0001575237,0.9914381,0.0001305736,0.00002708198,0.001742591],"study_design_scores_gemma":[0.00005795205,0.0006583473,0.6472009,0.00001399085,0.0001303257,0.004029037,0.0003068925,0.01038033,0.3346654,0.0004855798,0.002027074,0.00004403423],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997877,0.00009125013,0.001582653,0.0000181642,0.000001464131,0.000009997958,0.0001660226,0.00002231764,0.0002312541],"genre_scores_gemma":[0.9986425,0.00004309891,0.0008956302,0.00001578018,0.000001579703,0.000007622899,0.0001616891,0.0000101682,0.0002220486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001141489,"threshold_uncertainty_score":0.003535509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01627884041914551,"score_gpt":0.2550959630829794,"score_spread":0.2388171226638339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}