{"id":"W4200258848","doi":"10.1016/j.xcrm.2021.100455","title":"Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice","year":2021,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"IntelliView Technologies (Canada); University of Toronto; Université du Québec à Montréal; Polytechnique Montréal; Université de Montréal; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Cancer Research Society; Canadian Cancer Society Research Institute; Terry Fox Foundation; Fondation du cancer du sein du Québec; McGill University","keywords":"Mesenchymal stem cell; CD80; Antigen presentation; Stromal cell; Immunology; Cancer research; Antigen; Cancer immunotherapy; Chemokine; T cell; Cross-presentation; Antigen-presenting cell; Immunotherapy; Biology; Immune system; Cytotoxic T cell; CD40; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001624576,0.0003674275,0.0002040075,0.0003424098,0.00007343116,0.0002796209,0.0001861551,0.0003501414,0.001321632],"category_scores_gemma":[0.00007144947,0.0001373549,0.000208384,0.0001635993,0.0001328348,0.0002103252,0.0002306912,0.0005757402,0.0005004978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001612234,"about_ca_system_score_gemma":0.00017603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001416848,"about_ca_topic_score_gemma":0.0002540464,"domain_scores_codex":[0.9998341,0.0000253243,0.00001200201,0.00002655291,0.00005006724,0.00005196378],"domain_scores_gemma":[0.9999043,0.000008483773,0.00003796029,0.000009736475,0.000007534263,0.0000320989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008837521,0.00007167458,0.00007417367,0.00002199141,0.000003480392,0.00001765562,0.000007922511,0.0001348503,0.9975441,0.0001541019,0.00003773431,0.001843899],"study_design_scores_gemma":[0.00005031858,0.000855161,0.0009375528,0.000007809509,0.00001616271,0.0001621898,0.00001158339,0.001201411,0.9930574,0.00005509161,0.003642425,0.000002894392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855825,0.001326969,0.009711388,0.0001950934,0.00006371978,0.0001194148,0.0006170025,0.0001573003,0.002226654],"genre_scores_gemma":[0.9903899,0.0007361991,0.005162414,0.00007060751,0.00002103249,0.00008999199,0.0005093815,0.00003244618,0.002987971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001321632,"threshold_uncertainty_score":0.004421353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006854989528028608,"score_gpt":0.2091047864203481,"score_spread":0.2022497968923195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}