{"id":"W4200260682","doi":"10.1053/j.gastro.2021.12.269","title":"N6-Methyladenosine Reader YTHDF1 Promotes ARHGEF2 Translation and RhoA Signaling in Colorectal Cancer","year":2021,"lang":"en","type":"article","venue":"Gastroenterology","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":182,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Terry Fox Research Institute; Canada Foundation for Innovation; Princess Margaret Cancer Foundation","keywords":"RHOA; Cancer research; Biology; Chromatin immunoprecipitation; Carcinogenesis; Small interfering RNA; Ectopic expression; RNA; Metastasis; Small hairpin RNA; Cell biology; Molecular biology; Signal transduction; Gene expression; Cancer; Cell culture; Gene; Genetics; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001387366,0.0001599682,0.0001583097,0.0001649953,0.000250857,0.000285896,0.000130682,0.000297252,0.002021473],"category_scores_gemma":[0.0001381747,0.0001358108,0.0001655061,0.00009787403,0.0001721014,0.0001983797,0.0002004218,0.0004049221,0.0005044325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004006389,"about_ca_system_score_gemma":0.0001707869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001070126,"about_ca_topic_score_gemma":0.002677065,"domain_scores_codex":[0.9998833,0.00001663173,0.000006157607,0.00002927026,0.00002912308,0.00003547462],"domain_scores_gemma":[0.9999076,0.00001281222,0.00002243464,0.00001376739,0.00001075895,0.00003272012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002421459,0.00001217351,0.0005233602,0.00002665243,0.000003943794,0.00005935919,0.00001083137,0.00005942603,0.9972036,0.0001490734,0.0001719748,0.001537555],"study_design_scores_gemma":[0.00001839064,0.0001865019,0.01731911,0.000004455075,0.000008435561,0.000204147,0.00005381731,0.001053358,0.9768124,0.00007941465,0.004254146,0.000005775717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938369,0.002513862,0.0008620966,0.0002843392,0.00007427864,0.000006493485,0.0003048356,0.0001180226,0.001999075],"genre_scores_gemma":[0.9971766,0.0002601029,0.0003309684,0.00004153576,0.00001091868,0.000004137255,0.0001816341,0.00001092561,0.001983101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002021473,"threshold_uncertainty_score":0.006762445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01625436902152354,"score_gpt":0.2621199661146094,"score_spread":0.2458655970930858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}