{"id":"W4200261058","doi":"10.1093/geroni/igab046.2511","title":"Insertion of the protective APP A673T mutation by CRISPR/Cas9 base editing or PRIME editing.","year":2021,"lang":"en","type":"article","venue":"Innovation in Aging","topic":"Neurological Disease Mechanisms and Treatments","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"CRISPR; Genome editing; Mutation; Genetics; Amyloid precursor protein; Gene; Biology; Exon; Cas9; Molecular biology; Alzheimer's disease; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004766951,0.0007891686,0.0005962646,0.0005177381,0.0003148306,0.0006655381,0.0005475719,0.001048566,0.003044758],"category_scores_gemma":[0.0005433637,0.0003976826,0.0007724179,0.0002909881,0.0004393399,0.000342225,0.0004410902,0.001333219,0.001374191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004436797,"about_ca_system_score_gemma":0.0003256627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009469502,"about_ca_topic_score_gemma":0.001337647,"domain_scores_codex":[0.9994724,0.00005430436,0.00006883601,0.000160307,0.0001773748,0.00006672438],"domain_scores_gemma":[0.9996018,0.0001002345,0.0001481458,0.00006034279,0.00004080514,0.00004874513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001402232,0.00004123058,0.0001581487,0.0001538062,0.00002870272,0.0003180007,0.00004267529,0.0003396694,0.9906922,0.0004651022,0.0003814404,0.007238829],"study_design_scores_gemma":[0.00002898945,0.0002856734,0.0008273174,0.00001823536,0.00005715048,0.001043373,0.00001826843,0.002174788,0.9837113,0.0001420928,0.01166539,0.00002744441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7326506,0.004679497,0.2309494,0.0006656591,0.001112566,0.001827392,0.005555588,0.005360507,0.01719871],"genre_scores_gemma":[0.8501917,0.00182179,0.128339,0.0003537741,0.00004864021,0.0003920852,0.003856065,0.0006873046,0.01430974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003044758,"threshold_uncertainty_score":0.01018572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03793543821661027,"score_gpt":0.2933821870320548,"score_spread":0.2554467488154445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}