{"id":"W4200262298","doi":"10.1158/1535-7163.targ-21-p035","title":"Abstract P035: A phase 1 pharmacokinetic trial of single agent trametinib a MEK inhibitor in advanced cancer patients with hepatic dysfunction: An NCI Organ Dysfunction Working Group (ODWG) study (NCI 9591)","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; BC Cancer Agency; Princess Margaret Cancer Centre","funders":"","keywords":"Trametinib; Medicine; Pharmacokinetics; MEK inhibitor; Internal medicine; Dosing; Cancer; Oncology; Gastroenterology; Pharmacology; Kinase; MAPK/ERK pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001458945,0.0004172422,0.0007265366,0.0001560645,0.0001099672,0.00003672125,0.00008932761,0.00008995143,0.000233287],"category_scores_gemma":[0.00001811564,0.0003458148,0.000140463,0.0008123061,0.00008005069,0.0001093845,0.00004125543,0.0002765721,0.000001111341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007780061,"about_ca_system_score_gemma":0.0003495365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004221718,"about_ca_topic_score_gemma":0.002367491,"domain_scores_codex":[0.9973835,0.0001517053,0.0006487948,0.000654194,0.0007479684,0.0004138333],"domain_scores_gemma":[0.9987556,0.00004781277,0.0003130613,0.0003729418,0.0003728476,0.0001377851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1459156,0.0417444,0.1189521,0.0003413204,0.003592305,0.0006011932,0.007426176,0.0008860402,0.2212708,0.000003844491,0.00001653174,0.4592497],"study_design_scores_gemma":[0.5781987,0.05241011,0.2288141,0.001576607,0.006167293,0.00001281706,0.004646793,0.0004699039,0.1211503,0.0000408027,0.005098073,0.001414503],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922531,0.003846428,0.0001442367,0.0002162368,0.0009670418,0.002356537,0.00003871449,0.00005262536,0.0001250866],"genre_scores_gemma":[0.9976438,0.0004724226,0.0001622997,0.0005019664,0.0001989496,0.0008120397,0.00007826165,0.00008462449,0.00004563359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4578352,"threshold_uncertainty_score":0.9998994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03730481211282161,"score_gpt":0.3268553980221237,"score_spread":0.2895505859093021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}