{"id":"W4200262298","doi":"10.1158/1535-7163.targ-21-p035","title":"Abstract P035: A phase 1 pharmacokinetic trial of single agent trametinib a MEK inhibitor in advanced cancer patients with hepatic dysfunction: An NCI Organ Dysfunction Working Group (ODWG) study (NCI 9591)","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; BC Cancer Agency; Princess Margaret Cancer Centre","funders":"","keywords":"Trametinib; Medicine; Pharmacokinetics; MEK inhibitor; Internal medicine; Dosing; Cancer; Oncology; Gastroenterology; Pharmacology; Kinase; MAPK/ERK pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001247656,0.001425219,0.00171356,0.0004004794,0.0004739117,0.001009213,0.0008152149,0.001025919,0.004157646],"category_scores_gemma":[0.0006721264,0.0004836291,0.001291111,0.0004561743,0.0009092903,0.0007238725,0.000378128,0.00303843,0.0008572205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001083828,"about_ca_system_score_gemma":0.002306717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001797666,"about_ca_topic_score_gemma":0.00330531,"domain_scores_codex":[0.9995424,0.0001934192,0.00002746333,0.00009182904,0.00004505087,0.00009992581],"domain_scores_gemma":[0.9994523,0.00006011987,0.0000836718,0.00003494882,0.0000356015,0.0003334212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.795603,0.07210412,0.008338307,0.0004942605,0.00102908,0.000497498,0.0002499998,0.002389676,0.05710321,0.0002349494,0.005748068,0.05620782],"study_design_scores_gemma":[0.4099729,0.5648303,0.01664503,0.00002056775,0.0004198769,0.0003052118,0.000052021,0.001580635,0.004160345,0.0001389773,0.001841811,0.00003230766],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946313,0.0006082369,0.0004031819,0.000277054,0.00007047907,0.001576548,0.001251539,0.00009066606,0.001090951],"genre_scores_gemma":[0.9915403,0.0005520417,0.001010356,0.0005780279,0.0001293663,0.001546685,0.002325451,0.00002694415,0.002290805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004157646,"threshold_uncertainty_score":0.01390868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03730481211282161,"score_gpt":0.3268553980221237,"score_spread":0.2895505859093021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}